非编码RNA在砷毒性作用中调控机制的研究进展

Research progress on the regulatory mechanism of non-coding RNA in arsenic toxicity

砷是一种非金属元素,国际癌症研究机构已经明确砷及其化合物是致癌物质。砷及其化合物可经呼吸道、皮肤和消化道吸收,分布于肝、肾、肺以及皮肤中,并对其造成损伤。而非编码RNA与砷所致神经系统紊乱、细胞坏死、生殖毒性和癌变等密切相关。近年来,非编码RNA中的微小RNA(miRNAs)、长链非编码RNA(lncRNAs)和环状RNA(circRNAs)在砷诱导的各种疾病中的网络调控已成为新的研究领域。本文通过总结已有的科研成果,对miRNAs、lncRNAs和circRNAs在砷毒性中的作用机制进行阐述,为砷中毒的防治提供基础资料和理论依据。

Arsenic is a non-metallic element,and the International Agency for Research on Cancer has identified arsenic and its compounds as carcinogens.Arsenic and its compounds can be absorbed through the respiratory tract,skin and digestive tract,distributed in the liver,kidney,lung and skin,and cause damage.Non-coding RNAs are closely related to arsenic-induced nervous system disorders,cell necrosis,reproductive toxicity,and carcinogenesis.In recent years,the network regulation of microRNAs(miRNAs),long non-coding RNAs(lncRNAs),and circular RNAs(circRNAs)among non-coding RNAs in various diseases induced by arsenic has become a new research field.This paper summarizes the existing scientific research results,and expounds the mechanism of miRNAs,lncRNAs and circRNAs in arsenic toxicity,and provides basic data and theoretical basis for the prevention and treatment of arsenic poisoning.