三黄凝胶治疗聚合性痤疮的临床观察

Clinical observation on treating aggregate acne with the Sanhuang gel

目的:观察三黄凝胶治疗聚合性痤疮的临床疗效和安全性及其对患者生活质量的影响。方法:治疗组患者每晚外用三黄凝胶,对照组患者每晚外用阿达帕林凝胶。在此基础上两组患者均口服龙胆泻肝汤加减,4周为一个疗程,连续治疗2个疗程。用药期间停用影响本病药物评价的其他药物,并嘱患者禁辛辣刺激的食物。结果:治疗后,两组痤疮综合分级系统(Global Acne Grading System,GAGS)评分、皮肤病生活质量指数(Dermatology Life Quality Index,DLQI)量表评分较前均明显降低,差异均有统计学意义(P<0.05);治疗组GAGS评分、DLQI评分均低于对照组,差异均有统计学意义(P<0.05);治疗组不良反应发生率低于对照组,差异无统计学意义(P>0.05);治疗组临床有效率高于对照组(P<0.05)。结论:外用三黄凝胶治疗聚合性痤疮疗效确切,且不良反应小,值得临床推广应用。

Objective:To observe the clinical efficacy and safety of the Sanhuang gel(三黄凝胶)in the treatment of aggregate acne and its influence on quality of life of patients.Methods:The treatment group was treated with the Sanhuang gel topically every night,and the control group was given topical adapalene gel nightly.In addition,both groups were treated with the Longdan Xiegan decoction(龙胆泻肝汤)orally.4 weeks was a course of treatment,and the treatment lasted for 2 courses.During the medication period,other medicines that might affect the effects were not given to the patients,and spicy and stimulating food was not given also.Results:After treatment,the GAGS score and DLQI score in both groups were significantly decreased compared with before,with statistically significant differences(P<0.05).And the GAGS score and DLQI score in the treatment group were lower than the control group,P<0.05.The incidence of adverse reactions in the treatment group was lower than the control group,but the difference was not statistically significant(P>0.05).The clinical efficacy in the treatment group was higher than the control group(P<0.05).Conclusion:The Sanhuang gel is effective on aggregate acne,with fewer adverse reactions.It is worthy of clinical application.