代谢组学技术及其在耳鼻喉疾病中的应用探析

Metabonomics and its application in ear,nose and throat diseases

近五年来代谢组学技术被逐渐应用于耳鼻喉疾病研究,目前主要应用于疾病早期诊断、发病机制、疾病发展及预后评估、中医证型客观化、药物的疗效评价及作用机制方面,研究涉及变应性鼻炎、耳鸣、喉癌、鼻咽癌、小耳畸形等疾病。代谢组学在耳鼻喉疾病方面的研究虽然尚处于初步阶段,但在中医证型客观化和中医药治疗耳鼻喉疾病的研究中具有显著的临床价值。代谢组学的“整体性”和“动态性”特点与中医的“整体观念”和“辨证论治”理论相吻合,更适合于中医药多系统、多靶点的整体研究,有待进一步改进和挖掘。

Metabonomics technology has been gradually applied to the study on otolaryngology in the past five years.At present,it is mainly used in the early diagnosis,pathogenesis,disease development and prognosis evaluation,TCM syndrome type objectification,drug efficacy evaluation and action mechanism of otolaryngology.Research involves allergic rhinitis,tinnitus,laryngeal cancer,nasopharyngeal cancer,microtia and other diseases.Although the research on metabolomics in ENT diseases is still in the preliminary stage,it has significant clinical value in the study on TCM syndrome type objectification and TCM treatment of ENT diseases.The“integrity”and“dynamic”characteristics of metabolomics are consistent with the“integrity concept”and“diagnosis and treatment”theory of TCM,and are more suitable for the overall study on multiple systems and multiple targets in TCM,which need to be further improved and explored.