肺癌患者中医证型与降钙素原、C反应蛋白相关性分析

An analysis of the correlation between TCM syndrome types and procalcitonin and C-reactive protein in lung cancer patients

目的:探讨肺癌患者中医证型分布与降钙素原、C反应蛋白是否存在相关性。方法:回顾性分析77例肺癌患者的病例资料,中医证型分布采用聚类分析,降钙素原、C反应蛋白与中医证型的相关性探究采用秩和检验。结果:肺癌患者辨证为肺脾气虚型、热毒瘀结型、气滞血瘀型、气阴两虚型、痰湿瘀阻型,其中以肺脾气虚型最多见,热毒瘀结型最为少见。研究显示肺癌患者不同中医证型的C反应蛋白总体分布的差异不存在统计学意义(P> 0.05),肺癌患者的中医证型与降钙素原的差异存在统计学意义(P <0.05),肺脾气虚型患者的降钙素原值与气滞血瘀型患者(P <0.05)、热毒瘀结型患者(P <0.05)的差异存在统计学意义。结论:在临床中,肺癌患者辨证存在差异,可以参考降钙素原来辅助中医辨证分型,从而更好地指导肿瘤患者的辅助治疗,而C反应蛋白在研究中尚不能用于判断中医证型,需进一步完善研究以获得更严谨的数据。

Objective:To investigate correlation between the TCM syndromes distribution and procalcitonin and C-reactive protein of lung cancer patients.Methods:The data of 77 case was retrospectively analyzed.The distribution of TCM syndrome types was performed by cluster analysis.The correlation between procalcitonin,C-reactive protein and TCM syndrome types was explored by rank sum test.Results:The TCM syndrome types of lung cancer patients were the Qi-deficiency(气虚)of lung and spleen type,the heat-toxin stasis type,the Qi stagnation and blood stasis type,the deficiency of Qi(气)and Yin(阴)type,the phlegm-damp stasis type,among which the Qi-deficiency of lung and spleen type was the most common,and the heat-toxin stasis type was the most rare.This study showed that there was no statistically significant difference in the distribution of C-reactive protein among lung cancer patients with different TCM syndrome types(P>0.05),and there was a statistically significant difference between the TCM syndrome types and procalcitonin in lung cancer patients(P<0.05).The procalcitonin level in the Qi-deficiency of lung and spleen type patients is statistically different from the Qi stagnation and blood stasis type patients(P<0.05)and the heat-toxin stasis type patients(P<0.05).Conclusion:In clinical practice,there are differences in TCM syndrome types among patients with infected lung cancer.Lung cancer patients can refer to procalcitonin level to assist in clarifying TCM syndrome differentiation,so as to better guide the adjuvant treatment of tumor.In this study,C-reactive protein cannot be used to judge TCM syndrome types.The related research needs to be further refined to obtain more rigorous data.