法尼醇X受体激动剂在非酒精性脂肪性肝炎治疗中的应用

Application of farnesoid X receptor agonists in treatment of nonalcoholic steatohepatitis

非酒精性脂肪性肝炎(NASH)作为患病率较高的一种肝病,严重危害人类健康。近年来,法尼醇X受体相关药物在调节胆汁酸、糖脂代谢以及抑制炎症方面发挥了重要作用。总结了不同种类的法尼醇X受体激动剂在NASH治疗中的应用,为NASH的防治提供一定的依据。

Nonalcoholic steatohepatitis(NASH)is a liver disease with a relatively high prevalence worldwide and greatly threatens human health.In recent years,farnesoid X receptor-related drugs have played an important role in regulating the metabolism of bile acid,glu-cose,and lipids and inhibiting inflammation.This article summarizes the application of farnesoid X receptor agonists in the treatment of NASH,so as to provide a basis for the prevention and treatment of NASH.