支气管镜治疗放射性气管支气管炎的临床疗效

The Clinical Effect of Bronchoscopy in the Treatment of Radiation Bronchitis

目的分析支气管镜下介入治疗放射性气管支气管炎的临床疗效。方法随机选取福建省厦门弘爱医院和厦门大学附属第一医院2018年9月—2020年9月收治的放射性气管支气管炎患者60例,随机分组,每组30例,对照组患者给予常规治疗,观察组则在对照组的基础上增加支气管镜下介入治疗。比较两组治疗前后患者肺功能情况、肺部炎症相关因子监测值、肺部感染评分、治疗总有效率。结果治疗前两组患者肺功能情况、肺部炎症相关因子监测值、肺部感染评分比较,差异无统计学意义(P>0.05);治疗后两组患者的肺功能情况均显著提高,肺部炎症相关因子监测值、肺部感染评分均显著降低,差异有统计学意义(P<0.05)。其中,观察组第一秒用力呼气容积/预计值、第一秒用力呼气容积/肺活量、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肺部感染评分分别是(78.13±9.25)%、(67.19±7.21)、(1.52±0.21)ng/mL、(7.12±1.02)mg/L、(61.22±2.12)pg/mL、(3.11±1.01)分,对照组分别是(60.45±7.45)%、(58.25±6.24)%、(2.44±0.30)ng/mL、(9.25±1.60)mg/L、(121.45±2.55)mg/L、(4.25±1.71)分,两组对比,差异有统计学意义(t=8.153、5.135、13.760、6.148、99.481、3.144,P<0.05)。观察组放射性气管支气管炎治疗总有效率100.00%高于对照组70.00%,差异有统计学意义(χ^(2)=8.366,P<0.05)。结论支气管镜下介入治疗放射性气管支气管炎患者的疗效确切。

Objective To analyze the clinical efficacy of interventional treatment of radiation bronchitis under bronchoscopy.Methods Randomly selected 60 patients with radiation tracheobronchitis admitted to Xiamen Hongai Hospital and Xiamen University First Hospital from September 2018 to September 2020 were enrolled in Fujian Province.They were randomly divided into groups,30 cases in each group.Patients in the control group were given conventional treatment,and the observation group was given bronchoscopy interventional therapy on the basis of the control group.The lung function,pulmonary inflammation-related factors monitoring value,lung infection score,and total effective rate of treatment were compared between the two groups before and after treatment.Results Before treatment,comparison of lung function,pulmonary inflammation-related factors,and lung infection scores between the two groups of patients,the difference was not statistically significant(P>0.05).After treatment,the pulmonary function of the two groups of patients were significantly improved,and the monitoring values of lung inflammation-related factors and the lung infection score were significantly reduced,the difference was statistically significant(P<0.05).Among them,the forced expiratory volume in the first second/predicted value,the forced expiratory volume in the first second/vital capacity,tumor necrosis factor-α(TNF-α),high-sensitivity c-reactive protein(hs-CRP),interlenkin-6(IL-6),and lung infection scores of the observation group were(78.13±9.25)%and(67.19±7.21)%,(1.52±0.21)ng/mL,(7.12±1.02)mg/L,(61.22±2.12)pg/mL,(3.11±1.01)points.The control group was(60.45±7.45)%,(58.25±6.24)%,(2.44±0.30)ng/mL,(9.25±1.60)mg/L,(121.45±2.55)mg/L,(4.25±1.71)points,compared the two groups,the difference was statistically significant(t=8.153,5.135,13.760,6.148,99.481,3.144,P<0.05).The total effective rate of radiation bronchitis in the observation group was 100.00%higher than that in the control group by 70.00%,the difference was statistically significant(χ^(2)=8.366,P<0.05).Conclusion Bronchoscopy interventional therapy for patients with radiation tracheobronchitis is effective.