小剂量多巴胺联合人免疫丙种球蛋白治疗小儿重症肺炎的效果观察

Observation on the effect of low-dose dopamine combined with human immunoglobulin in the treatment of severe pneumonia in children

目的:研究小剂量多巴胺联合人免疫丙种球蛋白治疗小儿重症肺炎的效果。方法:选择2019年1月—2020年1月我院收治的80例重症肺炎患儿作为研究对象,采用随机数字表法分为对照组和观察组,每组40例。对照组采用小剂量多巴胺治疗,观察组在对照组基础上联用人免疫丙种球蛋白治疗。比较两组临床疗效、症状消失时间、血清超敏C反应蛋白(CRP)及降钙素(PCT)水平、肺功能[第一秒最大呼气量(FEV1)、用力呼气25%流速(MEF25)、用力肺活量(FVC)、用力呼气50%流速(MWV50)、最大呼气流速峰值(PEF)]和免疫功能(IgM、IgA和IgG)。结果:观察组总有效率为90.00%,高于对照组的72.5%,差异有统计学意义(P<0.05);观察组紫绀、咳嗽、啰音、气促、发热及三凹征症状消失时间短于对照组,差异有统计学意义(P<0.05);观察组血清CRP和PCT水平低于对照组,差异有统计学意义(P<0.05);观察组FEV1、FVC、MEF25、PEF以及MWV50高于对照组,差异有统计学意义(P<0.05);观察组IgM、IgA和IgG高于对照组,差异有统计学意义(P<0.05)。结论:小剂量多巴胺联合人免疫丙种球蛋白对小儿重症肺炎的效果较佳,可缩短患儿临床症状消失时间,改善炎症水平、免疫功能及肺功能,具有有效性。

Objective:To study the effect of low-dose dopamine combined with human immunoglobulin in the treatment of severe pneumonia in children.Methods:A total of 80 children with severe pneumonia admitted to our hospital from January 2019 to January 2020 were selected as the research objects,and were divided into control group and observation group by random number table method,with 40 cases in each group.The control group was treated with small dose of dopamine,and the observation group was treated with human immunoglobulin on the basis of control group.Clinical efficacy,symptom resolution time,serum levels of hypersensitive C-reactive protein(CRP)and calcitonin(PCT),lung function[maximum expiratory volume in the first second(FEV1),forced expiratory flow rate of 25%(MEF25),forced vital capacity(FVC),forced expiratory flow rate of 50%(MWV50),maximum expiratory flow rate of PEF]were compared between the two groups.And immune function(IgM,IgA and IgG).Results:The total effective rate of observation group was 90.00%,higher than that of control group 72.5%,the difference was statistically significant(P<0.05).The time of disappearance of cyanosis,cough,rales,shortness of breath,fever and three depressions was shorter in the observation group than in the control group,and the difference was statistically significant(P<0.05).The serum CRP and PCT levels in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).FEV1,FVC,MEF25,PEF and MWV50 in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05);The IgM,IgA and IgG of observation group were higher than those of control group,and the difference was statistically significant(P<0.05).Conclusion:Low dose dopamine combined with human immunoglobulin has a better effect on children with severe pneumonia,which can shorten the time for clinical symptoms to disappear,improve the level of inflammation,immune function and lung function,and has application effectiveness.