盐酸氨基葡萄糖胶囊联合塞来昔布治疗膝关节炎的临床疗效及不良反应分析

Clincial efficacy and safety of glucosamine hydrochloride plus celecoxib for gonarthritis

目的:探讨盐酸氨基葡萄糖胶囊联合塞来昔布治疗膝关节炎(KO)的临床疗效及安全性。方法:选取2018年2月—2021年1月我院收治的KO患者96例,按照随机数字表法分为对照组和试验组,每组48例。对照组给予塞来昔布片治疗,试验组在对照组治疗基础上联合盐酸氨基葡萄糖胶囊治疗,比较两组临床疗效、JOA评分及不良反应发生情况。结果:试验组显效率高于对照组,差异有统计学意义(P<0.05);两组治疗后JOA评分高于治疗前,且试验组高于对照组,差异有统计学意义(P<0.05);试验组不良反应发生率为4.17%,低于对照组的6.25%,但差异无统计学意义(P>0.05)。结论:盐酸氨基葡萄糖联合塞来昔布治疗KO疗效确切,可有效缓解患者临床症状,且不良反应轻微。

Objective:To investigate the clinical efficacy and safety of glucosamine hydrochloride capsules combined with celecoxib in the treatment of knee osteoarthritis(KO).Methods:Ninety-six patients with KO admitted to our hospital from February 2018 to January 2021 were randomly divided into control group and experimental group,with 48 cases in each group.The control group was treated with celecoxib tablets,and the experimental group was treated with glucosamine hydrochloride capsules on the basis of the control group.The clinical efficacy,JOA score and adverse reactions were compared between the two groups.Results:The significant efficiency of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).The JOA score of the two groups after treatment was higher than that before treatment,and the experimental group was higher than the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 4.17%,which was lower than 6.25%in the control group,but the difference was not statistically significant(P>0.05).Conclusion:Glucosamine hydrochloride combined with celecoxib is effective in the treatment of KO,which can effectively relieve the clinical symptoms of patients,and the adverse reactions are mild.