从痰瘀毒试论活血化瘀中药配合西药治疗2型糖尿病的效果及安全性分析

Effect and Safety of Traditional Chinese Medicine for Promoting Blood Circulation and Removing Blood Stasis Combined with Western Medicine in the Treatment of Type 2 Diabetes Mellitus

目的:基于痰瘀毒试论,探究采用活血化瘀中药配合西药治疗2型糖尿病后的临床效果及安全性。方法:选取本院2021年1月—2022年1月收诊的2型糖尿病患者85例,利用随机数字表法分为研究组43例、对照组42例,分别使用丹瓜方配合二甲双胍、单用二甲双胍进行治疗。经治疗3个月后,比较两组治疗总有效率,糖代谢指标[空腹血糖(FBG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA1c)],分析治疗后的不良反应发生率。结果:治疗后,研究组治疗总有效率为93.02%,高于对照组的76.19%,差异有统计学意义(P<0.05);研究组FBG、2 hPG、HbA1c低于对照组,差异有统计学意义(P<0.05);研究组总不良反应发生率为2.32%,低于对照组的19.05%,差异有统计学意义(P<0.05)。结论:丹瓜方配合二甲双胍治疗2型糖尿病的疗效显著,可在改善糖脂代谢的基础上,增强安全性,值得进行临床推广应用。

Objective:To explore the clinical effect and safety of traditional Chinese medicine for promoting blood circulation and removing blood stasis combined with western medicine in the treatment of type 2 diabetes based on phlegm and blood stasis toxin test.Methods:A total of 85 patients with type 2 diabetes who were admitted to our hospital from January 2021 to January 2022 were selected and divided into a study group of 43 cases and a control group of 42 cases by random number table method.Metformin treatment.After 3 months of treatment,the total effective rate,glucose metabolism indexes[fasting blood glucose(FBG),2 h postprandial blood glucose(2 hPG),glycosylated hemoglobin(HbA1C)]and the incidence of adverse reactions after treatment were compared between the two groups.Results:After treatment,the total effective rate of the study group was 93.02%,which was higher than 76.19%of the control group,and the difference was statistically significant(P<0.05).FBG,2 hPG and HbA1C in the study group were lower than those in the control group,and the difference was statistically significant(P<0.05).The total incidence of adverse reactions in the study group was 2.32%,which was lower than 19.05%in the control group,and the difference was statistically significant(P<0.05).Conclusion:Dangua prescription combined with metformin is effective in the treatment of type 2 diabetes,which can improve glucose and lipid metabolism and enhance safety,which is worthy of clinical application.