酮咯酸氨丁三醇片用于老年胃癌患者术后镇痛效果及对免疫功能的影响

Effect of ketorolac tromethamine tablets on postoperative analgesia and immune function in elderly patients with gastric cancer

目的回顾性研究分析酮咯酸氨丁三醇片用于胃癌患者术后镇痛效果及对免疫功能的影响。方法选取2020年7月至2021年10月在本院接受胃癌手术治疗的患者86例,按照镇痛方案不同分为两组,采用常规镇痛的患者作为对照组,在常规镇痛的基础上加服酮咯酸氨丁三醇片的患者作为观察组。依据VAS疼痛评分标准记录两组的疼痛得分来评价镇痛效果;酶联免疫吸附法检测血清炎症因子白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α);免疫功能的评价采用流式细胞仪检测T淋巴细胞亚群(CD^(+)_(3)、CD^(+)_(4)、CD^(+)_(8)、CD^(+)_(4)/CD^(+)_(8))水平的变化。结果两组患者术后的镇痛效果存在明显差异,同时间点观察组患者的VAS疼痛评分明显低于对照组,差异均具有统计学意义(P<0.05)。血清炎症因子IL-6以及TNF-α均显著低于对照组(P<0.05)。术后24h观察组T淋巴细胞亚群CD^(+)_(3)、CD^(+)_(4)、CD^(+)_(4)/CD^(+)_(8)高于对照组,CD^(+)_(8)低于对照组,差异均具有统计学意义(P<0.05)。两组术后不良反应发生率比较差异无统计学意义(P>0.05)。结论酮咯酸氨丁三醇片用于老年胃癌患者术后具有良好的镇痛效果,有效缓解了患者术后的疼痛,抑制机体内炎症反应,提高患者免疫力,多途径共同作用促进患者病情更好地康复,值得临床推广使用。

Objective To retrospectively analyze the effect of ketorolac tromethamine tablets on postoperative analgesia and immune function in patients with gastric cancer.Methods A total of 86 patients who received gastric cancer surgery in our hospital from July 2020 to October 2021 were selected and divided into two groups according to different analgesic regimens.Patients received conventional analgesia as the control group.On the basis of conventional analgesia,ketorolac tromethamine tablets were added as the observation group.The pain scores of the two groups were recorded according to the VAS pain score standard to evaluate the analgesic effect;serum inflammatory factors interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)were detected by enzyme-linked immunosorbent assay;immune function The evaluation of T lymphocyte subsets(CD^(+)_(3),CD^(+)_(4),CD^(+)_(8),CD^(+)_(4)/CD^(+)_(8))levels was detected by flow cytometry.Results There were significant differences in postoperative analgesic effects between the two groups of patients.At the same time point,the VAS pain score of the observation group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).Serum inflammatory factor IL-6 T lymphocyte subsets CD^(+)_(3),CD^(+)_(4),CD^(+)_(4)/CD^(+)_(8) in the observation group were higher than those in the control group at 24 hours after operation,and CD^(+)_(8) was lower than that in the control group,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of postoperative adverse reactions between the two groups(P>0.05).Conclusion Ketorolac tromethamine tablets have a good analgesic effect for elderly patients with gastric cancer after surgery,effectively relieve postoperative pain,inhibit the inflammatory response in the body,and improve the immunity of patients.The patient s condition can be better recovered,and it is worthy of clinical promotion.