基于组织系数的生物组织电特性分析方法研究

Novel method of analyzing electrical properties of biological tissue based on tissue coefficient

目的:针对生物组织电特性研究可对照性差及其常用特征参数计算复杂等难题,提出一种基于组织系数的生物组织电特性分析方法。方法:以生物组织电容与电导之比得到生物组织的时间系数,时间系数的倒数再除以频率得到其组织系数。计算基于文献数据开发的关于身体组织介电特性的开放数据库中54种生物组织的组织系数,并分析不同生物组织电阻抗的组织系数频谱。获取国内近年生物电特性研究数据,并与开放数据库中同类组织数据进行对比。结果:组织系数可提示生物组织电导与电容之比随频率变化规律和生物组织频散规律,能区分出血与正常脑组织且在较宽频域内能区分活皮肤与全皮肤。国内研究数据与开放数据库中数据相比,相似生物组织的组织系数在低频区域(f<1 kHz)差别较大。结论:基于组织系数的生物组织电特性分析方法可区分不同的生物组织,有望用于生物组织电容与电导变化较大,如皮肤角质含量和脑出血等基础和临床应用中。

Objective To propose a novel method for the analysis of electrical properties of the biological tissue based on the tissue coefficient to solve the problems of poor comparability and complicated calculation of characteristic parameters.Methods The time coefficient of the biological tissue was obtained by calculating the ratio of capacitance to conductance,and the tissue coefficient was got by dividing the reciprocal of the time cofficient with the frequency.The calculation was carried out for the tissue coefficients of 54 kinds of biological tissues in dielectric properties of body tissues open database based on the paper data,and the analysis was conducted for the tissue coefficient spectra of electrical impedance of different biological tissues.The recent research data of bioelectric properties in China were collected and compared with the data of similar tissues in the database.Results Tissue coefficients could suggest the changes of conductance to capacitance ratio with frequency and frequency dispersion pattern of biological tissues,and could distinguish hemorrhagic brain tissue from normal brain tissue and live skin from whole skin in a wide frequency domain.It's found that the tissue coefficients of similar biological tissues differed significantly in the low frequency region(f<1 kHz)by comparing the data from China's studies and the open database.Conclusion The method of electrical characterization of biological tissues based on tissue coefficients can distinguish different biological tissues,and is expected to be applied in basic and clinical medicine over biological tissues with large variations in capacitance and conductance such as skin keratin content and brain hemorrhage.