正念认知疗法联合艾司西酞普兰治疗广泛性焦虑障碍的临床效果分析

Analysis of the Clinical Effect of Mindfulness Cognitive Therapy Combined with Escitalopram in the Treatment of Generalized Anxiety Disorder

目的分析广泛性焦虑障碍疾病特点,评价联合正念认知疗法(mindfulness-based cognitive therapy,MBCT)与艾司西酞普兰治疗的预后效果。方法随机选择该院2020年1月—2021年1月收治的70例广泛性焦虑障碍患者,以随机数表法分组治疗。对照组(n=35)采取艾司西酞普兰治疗,观察组(n=35)联合MBCT治疗。比较两组患者的治疗情况,包括治疗效果、焦虑情绪、睡眠质量变化情况、生活质量、满意度情况。患者的焦虑情绪以汉密尔顿焦虑量表(HAMA)、焦虑自评量表(SAS)评估。患者的生活质量以健康调查简表(SF-36)评估。患者的睡眠质量以匹兹堡睡眠质量指数(PSQI)评估。结果观察组患者治疗8周后HAMA、SAS评分均明显低于对照组,差异有统计学意义(P<0.05);观察组患者治疗8周后的SF-36评分明显高于对照组,差异有统计学意义(P<0.05);观察组患者临床总有效率(94.28%)高于对照组总有效率(71.42%),差异有统计学意义(χ^(2)=6.436,P=0.011);观察组患者的总满意度明显高于对照组,差异有统计学意义(P<0.05);观察组患者治疗后睡眠质量评分明显低于对照组,差异有统计学意义(P<0.05)。结论MBCT与艾司西酞普兰联合治疗广泛性焦虑障碍整体效果显著,有效改善了患者的生活质量与睡眠质量,满足患者康复治疗需求。

Objective To analyze the characteristics of generalized anxiety disorder and evaluate the prognostic effect of combined mindfulness-based cognitive therapy(MBCT)and escitalopram treatment.Methods 70 patients with generalized anxiety disorder admitted to the hospital from January 2020 to January 2021 were randomly selected and treated by random number table method.The control group(n=35)was treated with escitalopram,and the observation group(n=35)was treated with MBCT.The treatment conditions of the two groups of patients were compared,including treatment effects,anxiety,changes in sleep quality,quality of life,and satisfaction.The anxiety of patients was evaluated by hamilton anxiety scale(HAMA)and self-rating anxiety scale(SAS).The patient's quality of life was assessed by the health survey brief(SF-36).The patient's sleep quality was assessed by the pittsburgh sleep quality index(PSQI).Results The HAMA and SAS scores of the observation group were significantly lower than those of the control group after 8 weeks of treatment,the difference was statistically significant(P<0.05).The SF-36 scores of patients in the observation group after 8 weeks of treatment were significantly higher than those in the control group,the difference was statistically significant(P<0.05).The total clinical effective rate(94.28%)of the observation group was higher than the total effective rate of the control group(71.42%),the difference was statistically significant(χ^(2)=6.436,P=0.011).The total satisfaction of patients in the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).The sleep quality scores of patients in the observation group were significantly lower than those in the control group after treatment,the difference was statistically significant(P<0.05).Conclusion The combination of MBCT and escitalopram in the treatment of generalized anxiety disorder has a significant overall effect,which effectively improves the quality of life and sleep quality of patients,and meets the needs of patients for rehabilitation.