中医辨证施治对绝经后骨质疏松患者的症状改善效果分析

Analysis of the Effect of TCM Treatment Based on Syndrome Differentiation on the Symptom Improvement of Postmenopausal Osteoporosis Patients

目的分析中医辨证施治对绝经期后骨质疏松患者的症状改善效果。方法方便选取该院2019年2月—2021年2月收治的106例绝经期后骨质疏松患者,随机分组法将患者分为中医组、常规组,各53例。常规组患者接受口服阿仑膦酸钠片、维生素D治疗,中医组患者接受中医辨证施治治疗。治疗2个月,比较两组患改善效果。结果①中医组总有效率(90.57%)高于常规组(71.70%),差异有统计学意义(χ^(2)=6.163,P<0.05);②中医组治疗后的促黄体生成素(LH)(19.3±2.7)IU/L、促卵泡刺激素(FSH)(23.8±6.5)IU/L均低于常规组(27.8±3.4)IU/L、(40.7±7.8)IU/L,且中医组治疗后的雌二醇(E2)(26.1±2.6)pg/mL高于常规组(16.7±2.9)pg/mL,差异有统计学意义(t=14.253、12.118、17.570,P<0.05);③中医组治疗后降钙素(CT)(60.5±12.7)μg/L、骨保护素(OPG)(138.9±13.4)pg/mL均高于常规组(51.2±9.9)μg/L、(106.8±12.2)pg/mL;且中医组骨钙素(BGP)(13.3±3.9)μg/L、Ⅰ型胶原交联C-末端肽(CTX-1)(0.21±0.09)ng/mL均低于常规组(18.4±3.0)μg/L、(0.30±0.08)ng/mL,差异有统计学意义(t=4.205、12.896、7.546、5.441,P<0.05);④中医组治疗后的中医证候积分(6.30±1.50)分明显低于常规组(8.80±1.90)分,且中医组治疗后股骨颈骨密度(0.79±0.07)g/cm^(3)、L2-4骨密度(0.89±0.08)g/cm^(3)、维生素D(28.7±5.6)ng/L水平均高于常规组(0.63±0.08)g/cm^(3)、(0.78±0.04)g/cm^(3),(25.9±4.8)ng/L,差异有统计学意义(t=7.518、10.958、8.953、2.764,P<0.05)。结论绝经期后骨质疏松患者采用中医辨证治疗能改善骨代谢和性激素异常现象,提高骨密度和维生素D水平,降低中医证候积分,减轻临床症状。

Objective To analyze the symptom improvement effect of TCM treatment based on syndrome differentiation on postmenopausal osteoporosis patients.Methods A total of 106 postmenopausal osteoporosis patients admitted to the hospital from February 2019 to February 2021 were conveniently selected.The patients were randomLy divided into traditional Chinese medicine group and routine group,with 53 cases in each group.Patients in the routine group received oral alendronate sodium tablets and vitamin D treatment,and patients in the traditional Chinese medicine group received treatment based on syndrome differentiation.After 2 months of treatment,the improvement effects of the two groups were compared.Results 1.The total effective rate(90.57%)in the traditional Chinese medicine group was higher than in the routine group(71.70%),and the difference was statistically significant(χ^(2)=6.163,P<0.05);2.The luteinizing hormone(LH)in the traditional Chinese medicine group after treatment(19.3±2.7)IU/L and follicle-stimulating hormone(FSH)(23.8±6.5)IU/L were lower than the routine group(27.8±3.4)IU/L and(40.7±7.8)IU/L,and the traditional Chinese medicine group after treatment Estradiol(E2)(26.1±2.6)pg/mL was higher than the routine group(16.7±2.9)pg/mL,the difference was statistically significant(t=14.253,12.118,17.570,P<0.05);3.Traditional Chinese medicine group treatment Post-CT(60.5±12.7)μg/L,OPG(138.9±13.4)pg/mL were higher than those in routine group(51.2±9.9)μg/L,(106.8±12.2)pg/mL;and traditional Chinese medicine group BGP(13.3±3.9)μg/L,CTX-1(0.21±0.09)ng/mL were lower than the routine group(18.4±3.0)μg/L,(0.30±0.08)ng/mL,the difference was statistically significant(t=4.205,12.896,7.546,5.441,P<0.05);4.The traditional chinese medicine group syndrome score(6.30±1.50)points in the traditional Chinese medicine group was significantly lower than that in the routine group(8.80±1.90)points,and the bone mineral density of the femoral neck in the traditional Chinese medicine group after treatment(0.79±0.07)g/cm^(3),L2-4 bone mineral density(0.89±0.08)g/cm^(3),vitamin D(28.70±5.60)ng/L levels were higher than those in the routine group(0.63±0.08)g/cm^(3),(0.78±0.04)g/cm^(3),(25.90±4.80)ng/L,the difference was statistically significant(t=7.518,10.958,8.953,2.764,P<0.05).Conclusion The use of TCM syndrome differentiation in postmenopausal patients with osteoporosis can improve bone metabolism and sex hormone abnormalities,increase bone density and vitamin D levels,reduce TCM syndrome scores,and relieve clinical symptoms.