检测血清免疫球蛋白和补体对儿童流感患儿的临床意义研究

Clinical Significance of Detection of Serum Immunoglobulin and Complement in Children with Influenza

目的研究检测血清免疫球蛋白和补体对儿童流感患儿的临床意义。方法随机选取2016年7月—2020年1月收治的60例流感患儿作为观察组,另同期选择健康体检儿童60名作为对照组,对两组儿童均实施血清免疫球蛋白和补体检验,分析检验结果。结果观察组IgG(30.23±3.98)g/L、IgA(16.87±2.23)g/L、IgM(14.98±2.83)g/L、TBiL(591.35±12.35)μmol/L均高于对照组,差异有统计学意义(t=37.830、48.530、32.840、353.200,P<0.05);PTA(36.87±10.24)%、ALB(20.33±1.23)g/L均低于对照组,差异有统计学意义(t=33.180、39.320,P<0.05);观察组补体C3(1.82±0.25)g/L、补体C4(0.68±0.02)g/L、CH50(122.25±2.52)U/L均高于对照组,差异有统计学意义(t=21.620、124.700、123.700,P<0.05)。结论血清免疫球蛋白和补体对儿童流感患儿具有较高诊断价值,能够为疾病后期治疗提供十分有利的参考依据。

Objective To study the clinical significance of detecting serum immunoglobulin and complement in children with influenza.Methods A total of 60 children with influenza who were treated from July 2016 to January 2020 were selected as the observation group,and 60 healthy children were randomly selected as the control group during the same period.Serum immunoglobulin and complement tests were performed on both groups of children,and the test results were analyzed.Results IgG(30.23±3.98)g/L,IgA(16.87±2.23)g/L,IgM(14.98±2.83)g/L,TBiL(591.35±12.35)μmol/L in the observation group were all higher than those in the control group,and the differences were statistically significant(t=37.830,48.530,32.840,353.200,P<0.05).The PTA(36.87±10.24)%and ALB(20.33±1.23)g/L of the observation group were lower than those of the control group,and the difference was statistically significant(t=33.180,39.320,P<0.05).Complement C3(1.82±0.25)g/L,complement C4(0.68±0.02)g/L,and CH50(122.25±2.52)U/L in the observation group were higher than those in the control group,and the difference was statistically significant(t=21.620,124.700,123.700,P<0.05).Conclusion Serum immunoglobulin and complement have high diagnostic value for children with influenza,and can provide a very favorable reference for the later treatment of the disease.