经尿道前列腺剜除术在良性前列腺增生治疗中的效果及对患者BUN、Scr、NSE、S100β蛋白水平的影响

The Effect of Transurethral Enucleation of the Prostate in the Treatment of Benign Prostatic Hyperplasia and Its Effect on BUN,Scr,NSE and S100βProtein Levels in Patients

目的探析经尿道前列腺剜除术在良性前列腺增生治疗中的效果及对患者尿素氮(BUN)、血肌酐(Scr)、神经元特异性烯醇化酶(NSE)、S100β蛋白的影响。方法回顾性分析2018年12月—2020年12月于该院接受治疗的70例良性前列腺增生患者的临床资料,以治疗术式的不同作为分组依据,应用电切镜经尿道前列腺电切术治疗的患者设为对照组(35例),应用电切镜经尿道前列腺剜除术治疗的患者设为观察组(35例)。记录两组治疗前后临床指标(BUN、Scr、NSE、S100β蛋白)水平、围术期指标与并发症发生情况。结果术后24 h,对照组BUN、Scr水平分别为(5.98±0.36)mmol/L、(78.65±3.81)μmol/L,高于观察组的(5.32±0.27)mmol/L、(73.38±2.09)μmol/L,差异有统计学意义(t=8.677、7.175,P<0.05),两组NSE与S100β蛋白水平基本一致,差异无统计学意义(P>0.05)。观察组膀胱造瘘管、尿管留置时间短于对照组,并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论应用经尿道前列腺剜除术为良性前列腺增生患者进行治疗,对其肾功能不会造成较大影响,且术后恢复速度快,无需长时间留置膀胱造瘘管及尿管,并发症发生率较低。

Objective To investigate the effect of transurethral enucleation of the prostate in the treatment of benign prostatic hyperplasia(BPH)and its effect on blood urea nitrogen(BUN),serum creatinine(Scr),neuron specific enolase(NSE)and S100βprotein.Methods The clinical data of 70 patients with benign prostatic hyperplasia who were treated in the hospital from December 2018 to December 2020 were retrospectively analyzed.Based on the different surgical treatment methods,the patients treated with urethra prostate electricity cut method were set as the control group(35 cases),and the patients treated with electricity cut mirror transurethral prostatic gouge out except for the treatment as the observation group(35 cases).Clinical indexes(BUN,Scr,NSE,S100βprotein)levels,perioperative indexes and complications were recorded before and after treatment in two groups.Results At 24 h after operation,the levels of BUN and Scr in the control group were(5.98±0.36)mmol/L and(78.65±3.81)μmol/L,respectively,which were higher than those in the observation group(5.32±0.27)mmol/L and(73.38±2.09)μmol/L,the difference was statistically significant(t=8.677,7.175,P<0.05),and the levels of NSE and S100βprotein in the two groups were basically the same,and the difference was not statistically significant(P>0.05).The time of bladder fistula and urinary catheter indwelling in the observation group was shorter than that in the control group,and the incidence of complications was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Transurethral enucleation of the prostate for patients with benign prostatic hyperplasia does not have a significant effect on the renal function,and the postoperative recovery is fast,there is no need for long-term indwelling cystostomy and urinary tube,and the incidence of complications is low.