细胞极性在牙发育中的研究进展

Research progress of cell polarity in tooth development

细胞极性是指由于极性蛋白复合物之间的相互协作或排斥,使细胞骨架、细胞器以及生物大分子等呈极性分布的特性。细胞各个部分实现不同生理功能需要细胞极性蛋白及分子的精密调控。细胞极性在牙发育中发挥着重要作用,特别对于成釉细胞和成牙本质细胞的分化和功能意义重大。文章就细胞极性及相关分子和通路在牙发育中的研究进展进行综述。

The cell polarity refers to the features of polar distribution of the cytoskeleton,organelles,and biological macromolecules caused by reciprocal cooperation or repulsion among polar protein complexes.Cell polarity is required for cells to carry out a variety of physiological functions.It allows various parts of a cell to fulfill different activities,thus is crucial for tooth development,especially for ameloblast and odontoblast differentiation and function.The research progress in cell polarity and its related molecules and pathways in tooth development is reviewed in this article.