神经丝轻链在帕金森病诊断与鉴别诊断中的研究进展

Research progression of neurofilament light chain in the diagnosis and differential diagnosis of Parkinson's disease

帕金森病是常见的神经系统变性疾病,疾病负担逐渐加重。神经丝轻链(NfL)作为一种高表达于大口径有髓鞘轴突的神经元胞质蛋白,可作为神经轴突损伤的标志物,是最有前景的帕金森病临床诊断与鉴别诊断的生物学标志物之一,对预测帕金森病严重程度和疾病进展、合并认知功能障碍亦具有重要作用,此外NfL联合影像学标志物亦具有较高的预测价值。本文综述脑脊液和血液NfL在帕金森病中的应用进展,以期对临床实践及后续研究提供帮助。

Parkinson's disease(PD)is a common neurodegenerative disease and the disease burden is increasing.Neurofilament light chain(NfL)is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons which may serve as a biomarker for axonal damage.NfL is one of the most promising biomarkers to be used in clinical diagnosis and differential diagnosis of PD and it also plays an important role in predicting the severity and progression of PD and associated cognitive disorders.Besides,NfL combined imaging biomarkers also has high predictive value.This review provides an overview of the progress achieved thus far exploring the assicaiton between NfL in cerebrospinal fluid or blood,with a view to be providing help for clinical practice and follow⁃up studies.