探讨小剂量阿司匹林治疗妊娠期高血压患者的临床疗效

Investigate the Clinical Efficacy of Low-dose Aspirin in the Treatment of Pregnancy Induced Hypertension

目的:探讨小剂量阿司匹林治疗妊娠期高血压患者的疗效及对患者血液高凝状态的影响。方法:本研究的观察对象为妊娠期高血压患者,为我院2019年1月至2020年5月收治的108例患者。根据治疗方法不同,将患者平均分成两组:研究组和对照组,各有患者54例。对照组的治疗药物为拉贝洛尔,研究组的治疗药物为小剂量阿司匹林与拉贝洛尔。经过14天的治疗后,评估临床疗效与不良妊娠发生率,比较治疗前后的血压和凝血功能指标水平。结果:研究组患者经过治疗后,总有效率较对照组显著提高(94.44%VS 77.78%)(P<0.05)。两组的SBP与DBP水平,治疗后的均低于治疗前的(P<0.05)。研究组的SBP与DBP水平治疗后低于对照组(P<0.05)。两组的PT、APTT水平,治疗后高于治疗前,FIB水平治疗后低于治疗前(P<0.05)。与对照组治疗后比较,研究组治疗后PT、APTT水平升高,FIB水平降低(P<0.05)。在不良妊娠发生率方面,研究组较对照组降低(11.11%VS 31.48%)(P<0.05)。结论:妊娠高血压患者加用小剂量阿司匹林可以降低患者血压水平,改善其血液的高凝状态及妊娠结局,取得的效果理想。

Objective:To investigate the effect of low-dose aspirin on patients with gestational hypertension and its effect on blood hypercoagulability.Method:The subjects of this study were 108 patients with gestational hypertension treated in our hospital from January 2019 to may 2020.According to different treatment methods,the patients were divided into two groups:the study group and the control group,with 54 patients in each group.The treatment drug of the control group was labetalol,and the treatment drug of the study group was low-dose aspirin and labetalol.After 14 days of treatment,the clinical efficacy and the incidence of adverse pregnancy were evaluated,and the blood pressure and coagulation function indexes before and after treatment were compared.Result:After treatment,the total effective rate in the study group was significantly higher than that in the control group(94.44%VS 77.78%)(P<0.05).The levels of SBP and DBP in the two groups after treatment were lower than those before treatment(P<0.05).The levels of SBP and DBP in the study group were lower than those in the control group after treatment(P<0.05).The levels of Pt and APTT in the two groups were higher after treatment than before treatment,and the level of FIB was lower after treatment(P<0.05).Compared with the control group after treatment,the levels of Pt and APTT in the study group increased and the level of FIB decreased after treatment(P<0.05).The incidence of adverse pregnancy in the study group was lower than that in the control group(11.11%VS 31.48%)(P<0.05).Conclusion:The addition of low-dose aspirin in patients with pregnancy induced hypertension can reduce the blood pressure level,improve the hypercoagulable state of blood and pregnancy outcome,and the effect is ideal.