淋病奈瑟菌脂寡糖疫苗研究进展

Research progress in Neisseria gonorrhoeae lipooligosaccharides vaccine

淋病奈瑟菌感染所致淋病是最常报告的传染病之一,随着淋病奈瑟菌抗生素耐药性的不断增加,淋病感染已成为全球重要的公共卫生问题,迫切需要开发安全有效的疫苗。脂寡糖(Lipooligosaccharide,LOS)存在于革兰阴性细菌外膜表面,其包含许多重要的抗原决定簇。近些年,大量研究表明LOS可能成为淋病奈瑟菌疫苗及其免疫疗法的最有潜力靶点。本文将就LOS结构、在淋病奈瑟菌感染作用机制、LOS疫苗研究进展以及面临的挑战进行综述,以期为后续相关研究提供参考。

Gonorrhea,caused by Neisseria gonorrhoeae,is one of the most frequently reported infectious diseases.With the increasing antibiotic resistance in Neisseria gonorrhoeae,gonorrhea has become a major public health problem worldwide,making it imperative to develop a safe and effective vaccine.Lipooligosaccharides(LOS),which exist on the outer surface of gram-negative bacteria,contain many important antigenic determinants.In recent years,a large number of studies have shown that LOS may become the most potential target of Neisseria gonorrhoeae vaccine and immunotherapy.This article reviewed the structure of LOS,its role in Neisseria gonorrhoeae infection,research progress in LOS vaccine and the challenges faced in vaccine development,aiming to provide reference for further study.