脱敏通鼻方联合西药治疗小儿过敏性鼻炎的效果探讨

Study on the Effect of Desensitization Tongbi prescription Combined with Western Medicine in the Treatment of Children with Allergic Rhinitis

目的探讨过敏性鼻炎(肺虚感寒证)患儿采用常规西药联合脱敏通鼻方治疗的临床效果与价值。方法选择2020年1月~2021年10月南京市六合区中医院接诊的过敏性鼻炎(肺虚感寒证)患儿100例,根据抛硬币方式分为观察组(正面,50例)与对照组(背面,50例),对照组采用常规西药(地氯雷他定干混悬剂+糠酸莫米松鼻喷雾剂)治疗,观察组在其基础上联合脱敏通鼻方治疗,比较治疗总有效率,评估两组患儿治疗前后症状(鼻痒、鼻塞、流涕、喷嚏)评分改善情况,检测对比两组患儿治疗前后炎症因子[肿瘤坏死因子-α(TNF-α)、白介素-4(IL-4)、白介素-5(IL-5)、白介素-10(IL-10)]水平变化。结果观察组临床治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组患儿治疗后鼻痒等症状评分均低于对照组,差异有统计学意义(P<0.05);另外,观察组患儿治疗后炎性指标测定结果低于对照组,差异有统计学意义(P<0.05)。结论小儿过敏性鼻炎(肺虚感寒证)可通过西药联合脱敏通鼻方治疗,对改善患儿症状、调节炎性水平具有确切效果,值得临床应用。

Objective To explore the clinical eff ect and value of conventional western medicine combined with desensitization Tongbi prescription in the treatment of allergic rhinitis(lung defi ciency and cold syndrome)children.Methods The research time range was determined from January 2020 to October 2021.The research subjects selected 100 children with allergic rhinitis(lung deficiency and cold syndrome),which were admitted to the Liuhe District Hospital of Traditional Chinese Medicine in Nanjing.The 100 children were randomly divided into two groups,namely observation group and control group,with 50 children in each group.The control group was treated with conventional western medicine(desloratadine dry suspension and mometasone furoate nasal spray),and the observation group was treated with desensitization Tongbi prescription.Then the treatment eff ect was compared,and the improvement of symptom scores(nasal itching,nasal congestion,runny nose,sneezing)of the two groups before and after treatment was evaluated.The changes in the levels of infl ammation[tumor necrosis factor(TNF-α),interleukin(IL-4),interleukin(IL-5),and interleukin 10(IL-10)]in the two groups before and after treatment were detected.Results The total eff ective rate of clinical treatment in the observation group was higher than that in the control group,and the diff erence was signifi cant(P<0.05),and the measurement results of infl ammatory indexes in the observation group after treatment were lower than those in the control group,and the diff erence was signifi cant(P<0.05).Conclusion Pediatric allergic rhinitis(lung defi ciency and cold syndrome)can be treated by western medicine combined with desensitization Tongbi prescription,which has a defi nite eff ect on improving the symptoms of children and regulating the level of infl ammation.