龙胆泻肝汤加减方联合异甘草酸镁治疗药物性肝炎临床研究

Clinical Study on Modified Longdan Xiegan Tang Combined with Magnesium Isoglycyrrhizinate for Drug-Induced Hepatitis

目的:观察龙胆泻肝汤加减方联合异甘草酸镁治疗药物性肝炎的临床疗效。方法:将68例药物性肝炎患者随机分为对照组与治疗组各34例。对照组给予异甘草酸镁治疗,治疗组在对照组的基础上联合龙胆泻肝汤加减方治疗。2组均连续治疗4周,观察比较2组临床疗效,肝功能指标谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)、总胆红素(TBil)水平变化及不良反应发生情况。结果:治疗组临床总有效率为97.06%,对照组为82.35%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组ALT、AST、ALP、TBil水平比较,差异无统计学意义(P<0.05)。治疗后,2组ALT、AST、ALP、TBil水平均较治疗前降低(P<0.05),且治疗组各项指标均低于对照组(P<0.05)。治疗组不良反应发生率为5.88%,对照组为14.71%,2组比较,差异有统计学意义(P<0.05)。结论:龙胆泻肝汤加减方联合异甘草酸镁治疗药物性肝炎疗效确切,可有效缓解患者临床症状,改善肝功能,并能降低不良反应发生率。

Objective: To observe the clinical effect of the therapy of modified Longdan Xiegan tang combined with magnesium isoglycyrrhizinate on drug-induced hepatitis. Methods:A total of 68 patients with drug-induced hepatitis were randomly divided into the control group and the treatment group,with 34 cases in each group. The control group was treated with magnesium isoglycyrrhizinate, and the treatment group was additionally treated with modified Longdan Xiegan tang based on the treatment of the control group. Both groups were continuously treated for four weeks. The clinical effects,changes of liver function indexes, including alanine aminotransferase(ALT), aspartate aminotransferase(AST), alkaline phosphatase(ALP),and total bilirubin(TBil),and adverse reactions were observed and compared between the two groups.Results:The total clinical effective rate was 97.06% in the treatment group and 82.35% in the control group,the difference being significant(P<0.05). Before treatment,there was no significant difference being found in the comparison of levels of ALT,AST,ALP and TBil between the two groups(P<0.05). After treatment,the levels of ALT,AST,ALP and TBil in the two groups were decreased when compared with those before treatment(P<0.05),and the above indexes in the treatment group were lower than those in the control group(P<0.05). The incidence of adverse reactions was 5.88% in the treatment group and 14.71% in the control group, the difference being significant(P<0.05). Conclusion: The therapy of Longdan Xiegan tang combined with magnesium isoglycyrrhizinate has a definite curative effect on drug-induced hepatitis,which can effectively relieve the clinical symptoms of patients, improve the liver function, and reduce the incidence of adverse reactions.