枣仁安神颗粒联合右佐匹克隆治疗阴虚火旺型失眠临床研究

Clinical Study on Zaoren Anshen Granules Combined with Eszopiclone for Insomnia of Yin Deficiency with Effulgent Fire Type

目的:观察枣仁安神颗粒联合右佐匹克隆治疗阴虚火旺型失眠的临床疗效。方法:选取102例阴虚火旺型失眠患者,按照不同治疗方式分成观察组和对照组,每组51例。对照组给予右佐匹克隆治疗,观察组在对照组基础上给予枣仁安神颗粒治疗,2组均连续治疗4周。比较2组临床疗效、不良反应发生率;比较2组治疗前后匹兹堡睡眠质量指数(PSQI)评分、入睡时间、觉醒次数及入睡潜伏期。结果:观察组总有效率96.1%,高于对照组84.3%(P<0.05)。治疗后,2组日间功能、入睡时间、睡眠障碍、睡眠效率、睡眠时间评分及总分均较治疗前降低(P<0.05),观察组日间功能、入睡时间、睡眠障碍、睡眠效率、睡眠时间评分及总分均低于对照组(P<0.05)。治疗后,2组睡眠时间均较治疗前延长(P<0.05),觉醒次数均较治疗前减少(P<0.05),入睡潜伏期均较治疗前缩短(P<0.05);观察组睡眠时间长于对照组(P<0.05),觉醒次数少于对照组(P<0.05),入睡潜伏期短于对照组(P<0.05)。观察组不良反应发生率3.9%,低于对照组19.6%(P<0.05)。结论:枣仁安神颗粒联合右佐匹克隆治疗阴虚火旺型失眠的临床疗效优于单纯使用右佐匹克隆治疗,能够有效改善患者的睡眠质量,且安全性高。

Objective:To observe the clinical effect of Zaoren Anshen granules combined with eszopiclone for insomnia of yin deficiency with effulgent fire type. Methods:A total of 102 cases of patients with insomnia of yin deficiency with effulgent fire type were selected and divided into the observation group and the control group according to different treatment methods, with 51 cases in each group. The control group was treated with eszopiclone, and the observation group was additionally treated with Zaoren Anshen granules based on the treatment of the control group. Both groups were treated for four weeks. The clinical effects and incidences of adverse reactions were compared between the two groups. Scores of Pittsburgh Sleep Quality Index(PSQI),the time to fall asleep,the times of wake after sleep onset and sleep latency were compared between the two groups before and after treatment. Results:The total effective rate was 96.1% in the observation group,higher than that of 84.3% in the control group(P<0.05). After treatment,scores of daytime function,the time to fall asleep,sleep disorder,sleep efficiency and sleep duration as well as the total scores in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05). After treatment,sleep duration in the two groups was prolonged when compared with that before treatment(P<0.05),the times of wake after sleep onset were decreased(P<0.05),and sleep latency was shortened(P<0.05). After treatment,sleep duration in the observation group was longer than that in the control group(P<0.05),the times of wake after sleep onset was fewer(P<0.05), and sleep latency was shorter(P<0.05). The incidence of adverse reactions was 3.9% in the observation group,lower than that of 19.6% in the control group(P<0.05). Conclusion:Zaoren Anshen granules combined with eszopiclone has a better clinical effect than the simple use of eszopiclone in the treatment of insomnia of yin deficiency with effulgent fire type. It can effectively improve sleep quality with high safety.