摘要
目的:观察益气活血法联合西药治疗气虚血瘀型肝硬化腹水的临床疗效。方法:选取90例气虚血瘀型肝硬化腹水患者,按随机数字表法分为对照组和试验组各45例。对照组给予西药对症治疗,试验组在对照组基础上给予益气活血法治疗,2组均治疗1个月。比较2组临床疗效,比较2组治疗前后24 h尿量、体质量、腹围及肝功能指标,记录2组不良反应。结果:试验组总有效率91.11%,高于对照组75.56%(P<0.05)。治疗后,2组24 h尿量均较治疗前增多(P<0.05),体质量均较治疗前降低(P<0.05),腹围均较治疗前缩小(P<0.05);试验组24 h尿量多于对照组(P<0.05),体质量低于对照组(P<0.05),腹围小于对照组(P<0.05)。治疗后,2组谷丙转氨酶(ALT)、谷草转氨酶(AST)、总胆红素(TBil)水平均较治疗前降低(P<0.05),白蛋白(Alb)水平均较治疗前升高(P<0.05);试验组ALT、AST、TBil水平均低于对照组(P<0.05),Alb水平高于对照组(P<0.05)。治疗期间,2组均未出现严重不良反应。结论:益气活血法联合西药治疗气虚血瘀型肝硬化腹水,能明显增强利尿作用,缓解患者的临床症状,改善其肝功能,且安全性高。
Objective:To observe the clinical effect of Yiqi Huoxue method combined with western medicine for ascites due to cirrhosis of qi deficiency and blood stasis type. Methods:A total of 90 cases of patients with ascites due to cirrhosis of qi deficiency and blood stasis type were selected and divided into the control group and the experiment group according to the random number table method,with 45 cases in each group respectively. The control group was given symptomatic treatment of western medicine,and the experiment group was additionally treated with Yiqi Huoxue method based on the treatment of the control group. Both groups were treated for one month. The 24-hour urine volume, body mass, abdominal circumference and liver function indexes in the two groups were compared before and after treatment. The clinical effects in the two groups were compared,and the adverse reactions were recorded. Results:The total effective rate was 91.11% in the experiment group,higher than that of 75.56% in the control group(P<0.05). After treatment,24-hour urine volume in the two groups was increased when compared with that before treatment(P<0.05),body mass decreased(P<0.05),and abdominal circumference smaller(P<0.05);24-hour urine volume in the experiment group was more than that in the control group(P<0.05), body mass lower(P<0.05), and abdominal circumference smaller(P<0.05). After treatment, levels of alanine aminotransferase(ALT), aspartate aminotransferase(AST) and total bilirubin(TBil) in the two groups were decreased when compared with those before treatment(P<0.05),and levels of Alb were increased(P<0.05);levels of ALT,AST and TBil in the experiment group were lower than those in the control group(P<0.05),and Alb level was higher(P<0.05). During treatment, there was no severe adverse reaction in the two groups. Conclusion: Yiqi Huoxue method combined with western medicine for ascites due to cirrhosis of qi deficiency and blood stasis type can effectively enhance diuretic effect,relieve clinical symptoms,and improve the liver function,with high safety.
作者
刘军
沈灵娜
徐瑾
陈洁
黄永宏
刘超
LIU Jun;SHEN Lingna;XU Jin;CHEN Jie;HUANG Yonghong;LIU Chao
出处
《新中医》
CAS
2022年第8期89-92,共4页
New Chinese Medicine
基金
浙江省医学会临床科研资金项目(2017ZYC-A79)。
关键词
肝硬化腹水
气虚血瘀证
益气活血法
24
h尿量
体质量
腹围
肝功能
Ascites due to cirrhosis
Qi deficiency and blood stasis type
Yiqi Huoxue method
24-hour urine volume
Body mass
Abdominal circumference
Liver function