复方木尼孜其颗粒联合强脉冲光治疗黄褐斑临床研究

Clinical Study on Compound Muniziqi Granules Combined with Intense Pulsed Light for Chloasma

目的:观察复方木尼孜其颗粒联合强脉冲光治疗黄褐斑的临床疗效及对患者性激素水平的影响。方法:选取88例黄褐斑患者,根据随机数字表法分为对照组和研究组,每组44例。研究组给予复方木尼孜其颗粒联合强脉冲光治疗,对照组给予维生素E、维生素C治疗,2组均治疗3个月。比较2组临床疗效及治疗前后皮损颜色、皮损面积评分和雌激素水平。结果:研究组愈显率90.91%,高于对照组65.91%(P<0.05)。治疗后,2组皮损颜色、皮损面积评分均较治疗前降低(P<0.05),研究组皮损颜色、皮损面积评分均低于对照组(P<0.05)。治疗后,2组卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E2)水平均较治疗前降低(P<0.05),研究组FSH、LH、E2水平均低于对照组(P<0.05)。结论:复方木尼孜其颗粒联合强脉冲光治疗黄褐斑临床效果确切,可有效改善皮损,降低性激素水平。

Objective:To observe the clinical effect of the therapy of compound Muniziqi granules combined with intense pulsed light on chloasma and its effect on the levels of sex hormones in patients. Methods:A total of 88 cases of patients with chloasma were selected and divided into the control group and the study group according to random number table method,with 44 cases in each group. The study group was given the therapy of compound Muniziqi granules combined with intense pulsed light,and the control group was treated with vitamin E and vitamin C. Both groups were treated for three months. The clinical effect,scores of skin lesion color and skin lesion area as well as the estrogen levels before and after treatment were compared. Results: The healing rate was 90.91% in the study group, higher than that of 65.91% in the control group(P<0.05). After treatment,the scores of skin lesion color and skin lesion area in both groups were decreased when compared with those before treatment(P<0.05),and the above two scores in the study group were lower than those in the control group(P<0.05). After treatment, the levels of follicle stimulating hormone(FSH), luteinizing hormone(LH) and estradiol(E2) in both groups were decreased when compared with those before treatment(P<0.05), and the above three levels in the study group were lower than those in the control group(P<0.05). Conclusion:The therapy of compound Muniziqi granules combined with intense pulsed light has a definite clinical effect on the treatment of chloasma,which can effectively improve the skin lesions and reduce the levels of sex hormones.