火针联合走罐疗法治疗原发性皮肤淀粉样变临床研究

Clinical Study on Fire Needling Combined with Sliding-Cupping Therapy for Primary Cutaneous Amyloidosis

目的:观察火针联合走罐疗法治疗原发性皮肤淀粉样变的临床疗效。方法:将原发性皮肤淀粉样变患者43例随机分成治疗组23例与对照组20例。2组均给予氯雷他定片口服,对照组加用卤米松软膏外涂,治疗组加用火针联合走罐疗法治疗,均连续治疗4周。观察2组治疗前后患者瘙痒、皮损肥厚评分变化,统计2组临床疗效、不良反应及复发情况。结果:治疗组总有效率为95.65%,对照组为65.00%,2组比较,差异有统计学意义(P<0.05)。治疗前,2组瘙痒、肥厚评分比较,差异无统计学意义(P>0.05);治疗后,2组瘙痒、肥厚评分均较治疗前降低(P<0.05),且治疗组2项评分均低于对照组(P<0.05)。随访3个月,治疗组无复发病例,对照组复发率为38.5%,2组比较,差异有统计学意义(P<0.05)。不良反应发生率治疗组为8.70%,对照组为5.00%,2组比较,差异无统计学意义(P>0.05)。结论:火针联合走罐疗法治疗皮肤淀粉样变疗效肯定,中长期临床疗效优于单用卤米松治疗,且复发率低,安全性良好。

Objective:To observe the clinical effect of fire needling combined with sliding-cupping therapy for primary cutaneous amyloidosis.Methods:A total of 43 cases of patients with primary cutaneous amyloidosis were randomly divided into the treatment group and the control group,with 23 and 20 cases in each group respectively.Both groups were given oral administration of loratadine tablets,the control group was additionally given external application with halometasone ointment,and the treatment group was additionally treated with needling combined with sliding-cupping therapy.Both groups were treated for four weeks.Before and after treatment,the changes in scores of pruritus and hypertrophic skin lesions in the two groups were observed.The clinical effects,adverse reactions and recurrences in the two groups were counted.Results:The total effective rate was 95.65%in the treatment group and 65.00%in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of scores of pruritus and hypertrophic skin lesions between the two groups(P>0.05).After treatment,the scores of pruritus and hypertrophic skin lesions in the two groups were decreased when compared with those before treatment(P<0.05),and the two scores in the treatment group were lower than those in the control group(P<0.05).After three-month follow-up,there was no recurrent case in the treatment group,and the recurrence rate was 38.5%in the control group,the difference being significant(P<0.05).The adverse reaction rate was 8.70%in the treatment group and 5.00%in the control group,there being no significance in the difference(P>0.05).Conclusion:The application of fire needling combined with sliding-cupping therapy has a definite clinical effect in treating primary cutaneous amyloidosis with low recurrence rate and good safety,whose midlong term clinical effect is better than that of simple halometasone.