电针耳迷走神经治疗腹泻型肠易激综合征临床研究

Clinical Study on Electro-Acupuncture at Auricular Vagus Nerve for Diarrhea-Predominant Irritable Bowel Syndrome

目的:观察电针耳迷走神经治疗腹泻型肠易激综合征(IBS-D)的临床疗效。方法:选取22例IBS-D患者,随机分为观察组12例和对照组10例,其中观察组剔除2例,最终纳入10例。对照组给予肠激灵方治疗,观察组给予电针耳迷走神经治疗,2组均治疗4周。比较2组治疗前后肠易激综合征症状严重程度量表(IBS-SSS)、肠易激综合征生活质量量表(IBS-QOL)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评分;比较2组不良反应。结果:治疗后,2组IBS-SSS评分均较治疗前降低(P<0.05),组间比较,差异无统计学意义(P>0.05)。治疗后,观察组心境恶劣、行为障碍、健康担忧、社会功能评分及总分,对照组心境恶劣、自体意象、健康担忧、关系拓展评分均较治疗前降低,差异均有统计学意义(P<0.05);2组上述IBS-QOL各项细则评分及总分比较,差异均无统计学意义(P>0.05)。治疗后,2组HAMD评分均较治疗前降低(P<0.05),组间比较,差异无统计学意义(P>0.05);2组HAMA评分均较治疗前降低(P<0.05),观察组HAMA评分低于对照组(P<0.05)。治疗期间,2组均未发生严重不良反应。结论:电针耳迷走神经治疗IBS-D能有效改善症状,提高患者的生活质量,缓解其焦虑、抑郁情绪,是一种安全有效的治疗方法。

Objective: To observe the clinical effect of electro-acupuncture at auricular vagus nerve for diarrhea predominant irritable bowel syndrome(IBS-D). Methods:A total of 22 cases of IBS-D patients were randomly divided into12 cases in the observation group and 10 cases in the control group,of which 2 cases were excluded from the observation group and then 10 cases were finally included. The control group was treated with Changjiling prescription, and the observation group was treated with electro-acupuncture at auricular vagus nerve. Both groups were treated for four weeks.Before and after treatment, the scores of Irritable Bowel Syndrome Symptom Severity Scale(IBS-SSS), Irritable Bowel Syndrome Quality of Life(IBS-QOL), Hamilton Depression Scale(HAMD) and Hamilton Anxiety Scale(HAMA) in the two groups were compared. The adverse reactions in the two groups were compared. Results:After treatment,the IBS-SSS scores in the two groups were decreased when compared with those before treatment(P<0.05), and there was no significant difference being found in the comparison of IBS-SSS scores between the two groups(P>0.05). After treatment,the scores of dysthymia,behavior disorder,health concerns and social function and the total scores in the observation group as well as the scores of dysthymia,self-image,health concerns and relationship development in the control group were decreased when compared with those before treatment, differences being significant(P<0.05);there was no significant difference being found in the comparison of the above scores of IBS-QOL between the two groups(P>0.05). After treatment,the HAMD scores in the two groups were decreased when compared with those before treatment(P<0.05),and there was no significant difference being found in the comparison of the HAMD scores between the two groups(P>0.05);the HAMA scores in the two groups were decreased when compared with those before treatment(P<0.05),and the HAMA score in the observation group was lower than that in the control group(P<0.05). During treatment,there was no serious adverse reaction in the two groups. Conclusion: Electro-acupuncture at auricular vagus nerve for IBS-D can effectively improve symptoms and quality of life, and relieve emotions like anxiety and depression of patients, which is a safe and effective treatment method.