耳穴压豆联合草酸艾司西酞普兰片治疗抑郁症临床研究

Clinical Study on Auricular Point Pressing with Beans Combined with Escitalopram Oxalate Tablets for Depression

目的:观察耳穴压豆联合草酸艾司西酞普兰片治疗抑郁症的临床疗效及对患者神经递质的影响。方法:选取80例抑郁症患者,按随机数字表法分为对照组和观察组各40例。对照组给予草酸艾司西酞普兰片治疗,观察组在对照组基础上加用耳穴压豆治疗,2组均治疗1个月。比较2组临床疗效;比较2组治疗前后汉密尔顿抑郁量表(HAMD)评分、症状评分及神经递质水平。结果:观察组总有效率90.00%,高于对照组72.50%(P<0.05)。治疗后,2组HAMD评分均较治疗前降低(P<0.05),观察组HAMD评分低于对照组(P<0.05)。治疗后,2组情绪低落、睡眠障碍、思维迟缓评分均较治疗前降低(P<0.05),观察组情绪低落、睡眠障碍、思维迟缓评分均低于对照组(P<0.05)。治疗后,2组去甲肾上腺素(NE)、5-羟色胺(5-HT)、多巴胺(DA)、谷氨酸(Glu)、γ-氨基丁酸(GABA)水平均较治疗前升高(P<0.05),观察组NE、5-HT、DA、Glu、GABA水平均高于对照组(P<0.05)。结论:耳穴压豆联合草酸艾司西酞普兰片治疗抑郁症,可有效缓解患者的临床症状,调节神经递质表达水平,具有较好的抗抑郁效果。

Objective:To observe the clinical effect of the therapy of auricular point pressing with beans combined with escitalopram oxalate tablets on depression and its effect on neurotransmitter in patients. Methods:A total of 80 patients with depression were divided into the control group and the observation group according to the random number table method,with 40 cases in each group. The control group was treated with escitalopram oxalate tablets,and the observation group was additionally treated with auricular point pressing with beans based on the treatment of the control group. Both groups were treated for one month. The clinical effects in the two groups were compared. Before and after treatment, the scores of Hamilton Rating Scale for Depression(HAMD),syndrome scores and levels of neurotransmitter expression were compared between the two groups. Results:The total effective rate was 90.00% in the observation group,higher than that of 72.50%in the control group(P<0.05). After treatment,the scores of HAMD in the two groups were decreased when compared with those before treatment(P<0.05),and the score of HAMD in the observation group was lower than that in the control group(P<0.05). After treatment, the scores of depression, sleep disorder and retardation of thinking in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05). After treatment,the levels of norepinephrine(NE),5-hydroxytryptamine(5-HT),dopamine(DA),glutamate(Glu) and γ-aminobutyric acid(GABA) in the two groups were increased when compared with those before treatment(P<0.05),and the above levels in the observation group were higher than those in the control group(P<0.05). Conclusion: The therapy of auricular point pressing with beans combined with escitalopram oxalate tablets for depression can effectively alleviate the clinical symptoms of patients and regulate the expression level of neurotransmitters,with great antidepressant effect.