多功能激光光电平台联合重组牛碱性成纤维细胞生长因子凝胶辅助治疗面部屏障受损性疾病的疗效观察

Efficacy of multifunctional laser photocoagulation platform combined with Recombinant Bovine Basic Fibroblast Growth Factor Gel in the treatment of facial barrier diseases

目的评价重组牛碱性成纤维细胞生长因子凝胶联合多功能激光光电平台辅助治疗面部屏障受损性疾病的疗效和安全性。方法回顾2020年6月~2021年3月门诊就诊的面部屏障功能受损性疾病患者共48例,其中面部接触性皮炎13例,面部脂溢性皮炎9例,玫瑰痤疮12例,糖皮质激素依赖性皮炎14例,采用重组牛碱性成纤维细胞生长因子联合多功能激光光电平台,每周治疗1次,共4周。分别于治疗前和4次治疗后1周进行疗效判定,采用临床症状评分和无创皮肤检测仪,对红斑、毛细血管扩张、丘疹、脓疱、瘙痒、紧绷、灼热、刺痛评分,测试皮肤经皮水分丢失、角质层含水量、PH值,脂质,红斑值,弹性值,48例患者治疗前后填写皮肤病生活质量指数量表(DLQI)。结果治疗后较治疗前临床症状明显改善(P<0.001),治疗后经皮水分丢失、红斑值,角质层含水量、脂质、弹性值差异有统计学意义(P<0.05),PH值无明显变化(P〉0.05),治疗前后DLQI评分有统计学意义(P<0.01)。结论重组牛碱性成纤维细胞生长因子联合多功能激光光电平台对面部屏障功能受损性疾病具有良好的辅助治疗作用,安全性高,显著提高患者生活质量。

Objective To evaluate the efficacy and safety of Recombinant Bovine Basic Fibroblast Growth Factor Gel combined with multifunctional laser photocoagulation platform in the treatment of facial barrier diseases.Method From June 2020 to March 2021,a total of 48 cases of facial barrier dysfunction diseases were reviewed,including 13 cases of facial contact dermatitis,9 cases of facial seborrheic dermatitis,12 cases of rose acne and 14 cases of glucocorticoid dependent dermatitis.Recombinant bovine basic fibroblast growth factor combined with multifunctional laser photoelectric platform were treated once a week for 4 weeks.Before treatment,the curative effect was judged one week after 4 times of treatment.Erythema,telangiectasia,papules,pustules,pruritus,tension,burning and tingling were scored by clinical symptom score and noninvasive skin detector.The skin transcutaneous water loss,cuticle water content,pH value,lipid and erythema value were tested.48 patients filled in the dermatology quality of life index(DLQI)before and after treatment.Result The clinical symptoms after treatment were significantly improved compared with those before treatment(P<0.001).There were significant differences in percutaneous water loss,erythema value,cuticle water content and lipid after treatment(P<0.05),no significant change in pH value(P>0.05),and there was significant difference in DLQI score before and after treatment(P<0.01).Conclusion Recombinant bovine basic fibroblast growth factor combined with multifunctional laser photoelectric platform has good adjuvant therapeutic effect,high safety and significantly improve the quality of life of patients with facial barrier dysfunction diseases.