可摘式牙周夹板修复联合米诺环素对重度牙周病中龈沟液炎性因子、牙齿美观度的影响

Effects of removable periodontal splint repair combined with minocycline on inflammatory factors of gingival crevicular fluid and tooth aesthetics in severe periodontal disease

目的探析重度牙周病应用联合策略(可摘式牙周夹板修复+米诺环素)的临床效果及对龈沟液炎性因子、牙齿美观度的影响。方法选择本院2021年1月-2022年2月就诊的80例重度牙周病患者作为研究对象,采用随机数字表法分为两组各40例。对照组实施单一可摘式牙周夹板修复治疗,观察组实施联合策略(可摘式牙周夹板修复+米诺环素)治疗。比较两组患者临床疗效、治疗前后龈沟液炎性因子(HMGB1、TREM-1、MCP-1)、牙齿美观度(IOTN-AC评分)。结果观察组临床有效率(95.00%)高于对照组(75.00%)(P<0.05)。治疗前,两组IOTN-AC评分、HMGB1、TREM-1、MCP-1对比,差异无统计学意义(P>0.05);治疗4周后两组上述指标均较治疗前明显降低,且观察组IOTN-AC评分、HMGB1、TREM-1、MCP-1低于对照组(P<0.05)。结论联合策略(可摘式牙周夹板修复+米诺环素)应用于重度牙周病中临床效果显著,可有效改善HMGB1、TREM-1、MCP-1炎症因子,提高牙齿美观度,值得临床推广。

Objective To explore the clinical effect of the combined strategy(removable periodontal splint repair+minocycline)for severe periodontal disease and its effect on inflammatory factors in gingival crevicular fluid and tooth aesthetics.Methods A total of 80 patients with severe periodontal disease who visited our hospital from January 2021 to February 2022 were selected as the research subjects,and divided into two groups with 40 cases in each group by random number table method.The control group was treated with a single removable periodontal splint repair,and the observation group was treated with a combined strategy(removable periodontal splint repair+minocycline).The clinical efficacy,gingival crevicular fluid inflammatory factors(HMGB1,TREM-1,MCP-1)and tooth aesthetics(IOTN-AC score)before and after treatment were compared between the two groups.Results The clinical effective rate(95.00%)of the observation group was higher than that of the control group(75.00%)(P<0.05).Before treatment,there was no significant difference in IOTN-AC score,HMGB1,TREM-1 and MCP-1 between the two groups(P>0.05).The scores of IOTN-AC,HMGB1,TREM-1 and MCP-1 were lower than those of the control group(P<0.05).Conclusion The combined strategy(removable periodontal splint repair+minocycline)has significant clinical effect in severe periodontal disease,can effectively improve HMGB1,TREM-1,MCP-1 inflammatory factors,and improve tooth aesthetics,which is worthwhile.clinical promotion.