MMP-13在皮肤相关疾病中的研究进展

Research Progress of MMP-13 in Skin-Related Diseases

基质金属蛋白酶(MMPs)是依赖锌的蛋白水解金属酶。MMP-13隶属于胶原酶亚群,在细胞外基质循环、癌细胞迁移、细胞生长、炎症、血管生成等方面发挥重要作用,它能降解胶原、明胶和聚集蛋白聚糖。在光老化中MMP-13的表达可受MAPK、NF-κB及TGF-β等多条信号通路影响。在癌症细胞中MMP-13能通过细胞外基质降解,导致肿瘤细胞的侵袭和转移,也可能直接调节多条控制组织稳态的信号通路。该文就MMP-13在皮肤相关疾病中的研究进行综述。

MMPs (matrix metalloproteinases) are zinc dependent proteolytic metalloenzymes.MMP-13 belongs to the collagenase subgroup and plays important roles in extracellular matrix circulation,cancer cell migration,cell growth,inflammation,angiogenesis,etc.It can degrade collagen,gelatin and aggregated proteoglycan.The expression of MMP-13 in photoaging can be affected by multiple signaling pathways such as MAPK,NF-κB and TGF-β.In cancer cells,MMP-13 can be degraded through extracellular matrix,leading to invasion and metastasis of tumor cells.It may directly regulate several signaling pathways that control tissue homeostasis.In this paper,the research of MMP-13 in skin-related diseases is reviewed.