高分辨质谱技术在全氟多氟化合物分析中的应用研究进展

Research Progress on Application of High-resolution Mass Spectrometry in Analysis of PFAS

全氟多氟化合物(PFAS)是工业生产和日常生活中应用普遍的一类化合物,由于其可能会对人类和环境带来一定的威胁而被广泛研究,已在全球许多环境和生物基质中检出,相关法规的演变是趋向对PFAS进行大类或整类列管。目前研究PFAS的传统方法主要采用质谱技术,其中基于低分辨质谱的目标物分析存在一定的局限性,而高分辨质谱因其分辨率高、质量精度高等特点在高通量和未知物分析上更具优势,可以同时实现目标物和非目标物的测定,满足和应对法规的不断更新和加严。该文主要综述了高分辨质谱在PFAS分析中的研究进展,包括相关的前处理方法,并通过环境样品、食品、消费品、人体样品等基质分别对其应用进行介绍,阐述了非靶向分析的流程,最后对未来发展趋势进行了展望。

Perfluoroalkyl and polyfluoroalkyl substances(PFAS)are widely used in industrial production and daily life.PFAS have been widely studied and consequently been detected in various environmental and biological matrices around the world due to their potential threats to humans and the environment.The development trend of relevant regulations is to manage PFAS as a chemical class.To date,mass spectrometry(MS)has been a traditional technique for PFAS analysis,among which the low-resolution MS is only limited for target analysis,while high-resolution MS with advantages of high resolution and high mass accuracy,could realize the high throughput analysis for both targets and non-targets at the same time,so as to meet and respond to the requirements for continuous updating and stricter of regulations.The research progress on high-resolution MS in PFAS analysis,including related pretreatment methods are reviewed in this paper.Furthermore,the applications of high-resolution MS in environmental samples,food,consumer goods,human samples and other matrix are also introduced,and the process of non-targeted analysis is described.Finally,knowledge gaps and future perspectives are identified.