摘要
microRNAs(miRNAs)是真核生物体内高度保守的非编码小分子RNA,具有多种生物学功能,参与疾病发生和发展、细胞增殖和分化等多种病理及生理过程的调控。miR-138作为一种肿瘤抑制因子已在肿瘤发生与治疗中被广泛研究和应用,同时在心血管及神经系统疾病、成骨分化、脂肪生成及卵巢功能维持等生命过程中具有调控作用。在总结分析miR-138相关功能最新研究进展的基础上,对miR-138的潜在研究方向进行了分析、讨论和展望,旨在为进一步深入探明miR-138的生物学功能提供参考和理论依据。
microRNAs(miRNAs)are highly conserved non-coding small RNA in eukaryotes.They have many biological functions and can participate in the regulation of disease,cell proliferation and differentiation and other biological process.miR-138 as a tumor suppressor has been widely studied in tumorigenesis and therapy and also plays a regulatory role in cardiovascular and neurological disorder processes,osteogenic differentiation,adipogenesis and ovarian function maintenance.In this paper,prospects for future research direction of miR-138 are analyzed and discussed on the basis of summarizing and analyzing the latest research progress of miR-138 related functions,aiming to provide reference and theoretical basis for exploring miR-138 biological functions in the future.
作者
冉宏标
王会
钟金城
RAN Hong-biao;WANG Hui;ZHONG Jin-cheng(Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization,Sichuan Province and Ministry of Education,Southwest Minzu University,Chengdu 610041,China)
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2022年第4期68-77,共10页
China Biotechnology
基金
四川省科技计划(2019YJ0257)
财政部和农业农村部国家现代农业产业技术体系(CARS-37)资助项目。
