虚拟生理心脏研究进展

Research Progress of Virtual Physiological Heart

心脏疾病是威胁人类生命健康的主要杀手之一。虚拟生理心脏建模是科学家研究多种心脏疾病形成机制和药物效果验证的新范式。它依托于计算机的强大计算能力从多个尺度对心脏的功能进行模拟仿真,最终提高科学实验的效率、透明度和可重复性,为心脏科学的研究提供新的路径。本文系统性的分析了多尺度虚拟心脏建模的主要研究方向、面临的挑战、应用现状和未来发展方向。从解剖结构建模、多尺度生理功能建模、多模态生理功能建模、多物种生理功能建模、高性能计算及可视化和个体化建模这五个方向进行全面梳理,并深入探讨了虚拟心脏建模在未来5~10年的几个重要发展方向。

Heart disease is one of the main killers to human being’s life and health.Virtual physiological heart modeling is a new method for scientists to study the mechanism of heart diseases and evaluate effects of drug.Based on the powerful computing power of the computer,a virtual physiological heart model can simulate the function of the heart from multiple scales,and finally improve the efficiency,transparency and repeatability of scientific experiments.Besides,a virtual physiological heart model can provide a new path for the research of cardiac science.In this paper,the authors systematically analyze the main challenges,application and future development of multi-scale virtual heart modeling,and comprehensively introduce the five directions:anatomical structure modeling,multi-scale physiological function modeling,multimodal physiological function modeling,multi-specie physiological function modeling,high-performance computing and visualization,and individualized modeling.Finally,the authors discuss several important development directions of virtual physiological heart modeling in the next 5~10 years.