中药有效成分防治骨肉瘤转移作用与机制研究进展

Research Progress on the Effect and Mechanism of Effective Components of Traditional Chinese Medicine in Preventing and Treating Osteosarcoma Metastasis

骨肉瘤是一种原发性、侵袭性恶性肿瘤,极易发生早期转移且缺乏有效治疗靶点。手术和放化疗及二者的联合应用是目前主要的治疗手段,但对转移性骨肉瘤患者总体生存率的提高仍未有明显改善。骨肉瘤在中医属于“癌病”范畴,中医药治疗骨肉瘤历史悠久,并且在防治骨肉瘤转移方面能够发挥积极作用,但其机制尚未十分明确。信号通路在骨肉瘤转移的发生过程中具有重要作用,并且是研究骨肉瘤转移的病理机制和治疗药物的作用靶点之一。近年来,针对中药有效成分防治骨肉瘤转移相关信号通路进行了大量研究,现将此做一综述,以期为中医药防治骨肉瘤转移、新药开发和临床诊治提供借鉴。

Osteosarcoma is a primary and aggressive malignant tumor, which is prone to early metastasis and lacks effective therapeutic targets. Surgery, chemoradiotherapy and the combination of the two are the main treatment methods at present, but the overall survival rate of patients with metastatic osteosarcoma has not been significantly improved.Osteosarcoma belongs to the category of "cancer disease" in traditional Chinese medicine. Traditional Chinese medicine has a long history in the treatment of osteosarcoma and can play an active role in the prevention and treatment of osteosarcoma metastasis, but its mechanism is not clear yet. Signaling pathway plays an important role in the pathogenesis of osteosarcoma metastasis and is one of the targets for the study of pathologic mechanism of osteosarcoma metastasis and therapeutic drugs. In recent years, large number of studies have been conducted on the signaling pathways related to the prevention and treatment of osteosarcoma metastasis by effective components of traditional Chinese medicine. This review is expected to provide reference for the prevention and treatment of osteosarcoma metastasis by traditional Chinese medicine, new drug development and clinical diagnosis and treatment.