部分补益类中药多糖成分在胃癌中的研究进展

Research Progress of Polysaccharide of Chinese Medicine for Tonifying Deficiency in Gastric Cancer

中药多糖成分是一类天然高分子多聚物,是由醛糖/酮糖通过糖苷键连接而成,是中药成分中发挥作用的主要的活性生物大分子。近年来国内外的相关研究指出中药中的多糖成分具有显著的抗肿瘤功效,而补益类中药具有“扶正”和“祛邪”双重功效,既可以扶正固本,提高机体免疫力,又可以发挥抗炎、抗肿瘤、抗病毒等功效,更加符合中医治疗胃癌的研究方向和治疗原则。本文通过PubMed、Medline、Cochrane、CNKI、SinoMed、万方、维普等国内外医学类数据库查阅了近20年的相关文献,对国内外文献中已报道的具有补益功效的中药多糖成分在胃癌的作用进行总结,旨在为胃癌的中医药治疗提供临床指导,同时为后续中药多糖的药理活性的研究及健康产品开发利用提供参考依据。

Polysaccharides of traditional Chinese medicine(TCM) are a kind of natural polymer by aldose or ketone sugar through glycoside bond. It is the main biological macromolecule in Chinese herbal medicine and one of the main active components in traditional Chinese medicine. In recent years, related studies at home and abroad have pointed out that the polysaccharides in traditional Chinese medicine have remarkable anti-tumor effect, while tonifying traditional Chinese medicine has the dual functions of "strengthening the spirit" and "dispelling evil", which can not only strengthen the body and improve the body’s immunity, but also play the functions of anti-tumor, anti-inflammatory and anti-virus. By searching PubMed, Medline, Cochrane, CNKI, SinoMed, Wanfang, VIP medical databases at home and abroad for nearly 20 years, this paper summarized the effects of Chinese medicine polysaccharides reported in domestic and foreign literature on gastric cancer. The aim is to provide clinical guidance for the treatment of gastric cancer and to provide reference for the study of pharmacological activity and the development and utilization of health products.