从痰、虚、郁角度调节肥胖患者的肠道菌群

Adjust the Intestinal Flora of Obese Patients from the Perspective of Phlegm, Deficiency and Depression

随着生活质量的提升,饮食习惯发生改变,社会压力不断增大,我国肥胖患病率逐渐显现出流行态势,并作为其他多种疾病的独立危险因素,对病患的生存状态造成巨大影响。有“机体最大的微生态系统”之称的肠道菌群,是调节脂肪能量积聚的环境因素,不仅能够协助调节消化、营养、免疫等一系列身体机能,还能够直接参与宿主胆汁酸、短链脂肪酸和碳水化合物的代谢过程,与肥胖的发生发展关系密切。已有研究证实,肥胖之人与形体适中之人的肠道菌群差异颇大,通过调节肠道菌群改善肥胖,已成为临床研究热点。中医药对于肥胖的认知历史源远流长,具备独特的辨证思维优势及优异的诊疗效果,不仅可以通过肠道吸收发挥作用,也可以直接以菌群作为靶点发挥疗效。紧跟中医继承与发展步伐,从痰、虚、郁三个角度进行肠道菌群的调节,以期为今后中医药治疗肥胖事业添砖加瓦。

With the quality of life has been improved, dietary habits have changed, and social pressure is increasing, the prevalence of obesity in China has gradually shown an epidemic trend, and as an independent risk factor for a variety of other diseases, it has a huge impact on the survival of patients. Intestinal flora, known as "the largest microecosystem of the body", and an environmental factor regulating fat energy accumulation, it can not only assist in regulating a series of bodily functions such as digestion, nutrition and immunity, but also directly participate in the metabolic process of bile acids, short-chain fatty acids and carbohydrates of the host, which is closely related to the occurrence and development of obesity. Studies have confirmed that the intestinal flora of obese people and people with moderate body size are quite different, and improving obesity by regulating intestinal flora has become a clinical research hotspot. Traditional Chinese medicine has a long history of cognition of obesity, and has a unique advantage of syndrome differentiation and excellent diagnosis and treatment effect. It can not only play a role through intestinal absorption, but also play a role directly by targeting bacteria as a target. Keeping up with the pace of inheritance and development of traditional Chinese medicine,we should regulate intestinal flora from the perspectives of phlegm, deficiency and depression, in order to contribute to the cause of obesity treatment by traditional Chinese medicine in the future.