贝那普利联合酒石酸美托洛尔对老年高血压合并心力衰竭患者血压控制及心室重塑的影响

Effect of Benazepril combined with Metoprolol Tartrate on blood pressure control and ventricular remodeling in elderly patients with hypertension and heart failure

目的探讨贝那普利联合酒石酸美托洛尔在老年高血压合并心力衰竭患者中的应用价值。方法选取2019年1月至2021年1月龙口市第二人民医院收治的84例老年高血压合并心力衰竭患者作为研究对象,按照随机数字表法将其分为对照组(42例)和研究组(42例)。对照组患者采用贝那普利治疗,研究组患者采用贝那普利联合酒石酸美托洛尔治疗,均持续用药6个月。比较两组患者的血压控制效果、心室重塑情况、心功能、半乳糖凝集素-3(Gal-3)、微量白蛋白尿(MAU)及不良反应发生情况。结果治疗前,两组患者的舒张压(DBP)、收缩压(SBP)、左室后壁厚度(LVPWT)、左室心肌重量指数(LVMI)、舒张末期室间隔(IVST)、左室射血分数(LVEF)、舒张期内径(LVEDD)、收缩期内径(LVESD)、Gal-3、MAU比较,差异无统计学意义(P>0.05);治疗后,研究组患者的DBP、SBP、LVPWT、IVST、LVEDD、LVESD、Gal-3、MAU低于对照组,LVMI、LVEF高于对照组,差异有统计学意义(P<0.05);两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论贝那普利联合酒石酸美托洛尔能够有效控制老年高血压合并心力衰竭患者的血压水平,改善心室重塑,降低Gal-3、MAU水平,促进患者心功能恢复,安全可靠。

Objective To explore the application value of Benazepril combined with Metoprolol Tartrate in elderly patients with hypertension and heart failure.Methods A total of 84 elderly patients with hypertension and heart failure admitted to the Second People′s Hospital of Longkou City from January 2019 to January 2021 were selected as subjects,and divided into a control group(42 cases)and a study group(42 cases)according to the random number table method.The control group was treated with Benazepril,and the study group was treated with Benazepril combined with Metoprolol Tartrate,both of which were treated continuously for 6 months.The blood pressure control effect,ventricular remodeling,heart function,galectin-3(Gal-3),microalbuminuria(MAU)and adverse reactions were compared between the two groups.Results Before treatment,there were no statistical significances in diastolic blood pressure(DBP),systolic blood pressure(SBP),left ventricular posterior wall thickness(LVPWT),left ventricular mass index(LVMI),interventricular septal thickness(IVST),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic dimension(LVESD),Gal-3,MAU between the two groups(P>0.05).After treatment,the DBP,SBP,LVPWT,IVST,LVEDD,LVESD,Gal-3 and MAU of the study group were lower than those of the control group,and LVMI and LVEF of the study group were higher than those of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Benazepril combined with Metoprolol Tartrate can effectively control blood pressure in elderly patients with hypertension and heart failure,improve ventricular remodeling,reduce Gal-3 and MAU levels,and promote the recovery of cardiac function in patients,which is safe and reliable.