艾拉莫德治疗老年原发性干燥综合征的效果及对患者SSDAI、ESSPRI评分的影响

Effect of iguratimod in the treatment of senile primary Sjogren's syndrome and its influences on SSDAI and ESSPRI scores of patients

目的探讨艾拉莫德治疗老年原发性干燥综合征(pSS)的效果及对患者干燥综合征疾病活动指数(SSDAI)、干燥综合征患者报告指数(ESSPRI)评分的影响。方法选取2019年3月至2021年3月我院接收的40例老年pSS患者作为研究对象,依据患者入院编号的奇偶性将其随机分为观察组(20例,艾拉莫德+硫酸羟氯喹+泼尼松)与对照组(20例,硫酸羟氯喹+泼尼松)。比较两组患者的实验室指标、疾病活动情况、干燥程度、疼痛程度、相关试验结果及不良反应发生情况。结果治疗后,两组的ESR及IgG、RF、IL-17、TGF-β_(1)水平均降低,且观察组明显低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的SSDAI、ESSPRI、VAS评分均降低,Schirmer试验、唾液试验结果均改善,且观察组明显优于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论艾拉莫德治疗老年pSS的效果显著,可降低各项实验室指标,缓解患者的疾病症状,且安全性较佳,值得临床推广。

Objective To investigate the effect of iguratimod in the treatment of senile primary Sjogren's syndrome(pSS)and its influences on the Sjogren's syndrome disease activity index(SSDAI)and the EULAR Sjogren's syndrome patient reported index(ESSPRI)scores of patients.Methods A total of 40 senile patients with pSS received in our hospital from March 2019 to March 2021 were selected as the research objects,and the patients were randomly divided into observation group(20 cases,iguratimod+hydroxychloroquine sulfate+prednisolne)and control group(20 cases,hydroxychloroquine sulfate+prednisolne)according to the parity of the patients'admission numbers.The laboratory indicators,disease activity,degree of dryness,degree of pain,related test results and occurrence of adverse reactions were compared between the two groups.Results After treatment,ESR and the levels of IgG,RF,IL-17,TGF and TGF-β_(1) in the two groups decreased,and those in the observation group were significantly lower than the control group,the differences were statistically significant(P<0.05).After treatment,the SSDAI,ESSPRI and VAS scores of the two groups decreased,and the results of Schirmer test and saliva test improved,and those in the observation group were significantly better than the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Iguratimod in the treatment of senile pSS has a significant effect,it can reduce various laboratory indicators,relieve the disease symptoms of patients,and has a good safety,which is worthy of clinical promotion.