帕罗西汀联合草酸艾司西酞普兰治疗双相情感障碍抑郁发作的临床效果

Clinical effect of paroxetine combined with escitalopram oxalate in the treatment of depressive episode of bipolar disorder

目的探究帕罗西汀联合草酸艾司西酞普兰治疗双相情感障碍抑郁发作的临床效果。方法选取2018年1月至2020年12月在我院接受治疗的100例双相情感障碍抑郁发作患者,根据治疗方案的不同将其分为对照组和观察组,各50例。对照组给予帕罗西汀治疗,观察组给予帕罗西汀联合草酸艾司西酞普兰治疗。比较两组的躁狂、抑郁情况、血清相关因子水平及临床疗效。结果治疗后,两组患者的BRMS、HAMD-17评分均降低,且观察组低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的5-HT、GSH-Px、SOD水平高于对照组,IL-1β、TNF-α、S100β水平低于对照组,差异具有统计学意义(P<0.05)。观察组的治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。结论帕罗西汀联合草酸艾司西酞普兰治疗双相情感障碍抑郁发作能有效改善患者的血清相关因子水平,缓解其躁狂、抑郁症状,疗效显著。

Objective To explore the clinical effect of paroxetine combined with escitalopram oxalate in the treatment of depressive episode of bipolar disorder.Methods One hundred patients with depressive episode of bipolar disorder treated in our hospital from January 2018 to December 2020 were selected and divided into control group and observation group according to different treatment schemes,with 50 cases in each group.The control group was treated with paroxetine,and the observation group was treated with paroxetine combined with escitalopram oxalate.The mania and depression,the level of serum related factors and clinical efficacy were compared between the two groups.Results After treatment,the scores of BRMS and HAMD-17 in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of 5-HT,GSH-Px,SOD in the observation group were higher than those in the control group,and the levels of IL-1β,TNF-α,S100βin the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).The total effective rate of the observation group was significantly higher than that of the control group,the difference was statistically significant(P<0.05).Conclusion Paroxetine combined with escitalopram oxalate in the treatment of bipolar disorder depressive episode can effectively improve the level of serum related factors,relieve patients with mania and depressive symptoms,with significant efficacy.