头孢呋辛钠联合经鼻高流量湿化氧疗治疗慢性阻塞性肺疾病急性加重期合并Ⅱ型呼吸衰竭的效果及对患者MMP-9、TIMP-1水平的影响

Effect of cefuroxime sodium combined with nasal high-flow humidification oxygen therapy on acute exacerbation of chronic obstructive pulmonary disease complicated with type II respiratory failure and its influences on the levels of MMP-9 and TIMP-1 of patients

目的探讨头孢呋辛钠联合经鼻高流量湿化氧疗治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并Ⅱ型呼吸衰竭的效果。方法选取2019年12月至2020年11月我院收治的150例AECOPD合并Ⅱ型呼吸衰竭患者进行研究,采用抽签法以单双号随机分组形式将其分为对照组和观察组,各75例。对照组采用经鼻高流量湿化氧疗治疗,观察组在此基础上联合头孢呋辛钠治疗。比较两组的治疗效果。结果治疗后,观察组的PaO_(2)高于对照组,PaCO_(2)、RR低于对照组(P<0.05)。治疗后,观察组的FEV1、FEV1%及FEV1/FVC高于对照组(P<0.05)。治疗后,观察组的MMP-9、TIMP-1水平均低于对照组(P<0.05)。治疗后,观察组MDA水平低于对照组,SOD、T-AOC水平高于对照组(P<0.05)。结论头孢呋辛钠联合经鼻高流量湿化氧疗治疗AECOPD合并Ⅱ型呼吸衰竭不仅能促进患者血气分析指标、肺功能、呼吸功能改善,也能降低MMP-9、TIMP-1水平,值得临床推广应用。

Objective To explore the effect of cefuroxime sodium combined with nasal high-flow humidification oxygen therapy in the treatment of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)complicated with typeⅡrespiratory failure.Methods A total of 150 patients with AECOPD complicated with typeⅡrespiratory failure admitted in our hospital from December 2019 to November 2020 were selected for study,and the patients were divided into control group and observation group by single and double sign random grouping form with drawing lots,with 75 cases in each group.The control group was treated with nasal high-flow humidification oxygen therapy,and the observation group was treated with cefuroxime sodium on this basis.The treatment effects of the two groups were compared.Results After treatment,PaO_(2) of the observation group was higher than that of the control group,and PaCO_(2) and RR were lower than those of the control group(P<0.05).After treatment,FEV1,FEV1%and FEV1/FVC in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of MMP-9 and TIMP-1 in the observation group were lower than those in the control group(P<0.05).After treatment,the MDA level of the observation group was lower than that of the control group,and the SOD and T-AOC levels were higher than those of the control group(P<0.05).Conclusion Cefuroxime sodium combined with nasal high-flow humidification oxygen therapy in the treatment of AECOPD complicated with typeⅡrespiratory failurey can not only promote the improvement of blood gas analysis indexes,lung function and respiratory function,but also reduce the levels of MMP-9 and TIMP-1,which is worthy of popularization and application in clinic.