曲美他嗪联合依折麦布辛伐他汀对老年冠心病患者心功能、血管内皮功能的影响

Effects of trimetazidine combined with ezetimibe/simvoastatin on cardiac function and vascular endothelial function in elderly patients with coronary heart disease

目的探讨曲美他嗪联合依折麦布辛伐他汀治疗老年冠心病患者的临床效果。方法选择2019年11月至2020年2月我院收治的90例老年冠心病患者作为研究对象,根据治疗方案将其分为对照组和观察组,各45例。两组入院后均给予常规治疗,对照组加施依折麦布辛伐他汀,观察组在对照组基础上加施曲美他嗪。比较两组的治疗效果。结果治疗后,观察组的LVDd、LVDs低于对照组,LVEF高于对照组(P<0.05)。治疗后,观察组的vWF、AngⅡ水平低于对照组,VEGF水平高于对照组(P<0.05)。治疗后,观察组的MMP-9、SAA水平低于对照组(P<0.05)。结论曲美他嗪联合依折麦布辛伐他汀可改善老年冠心病患者的心功能及血管内皮功能,调节MMP-9、SAA水平,值得临床推广和应用。

Objective To investigate the clinical effect of trimetazidine combined with ezetimibe/simvoastatin in the treatment of elderly patients with coronary heart disease.Methods A total of 90 elderly patients with coronary heart disease treated in our hospital from November 2019 to February 2020 were selected as the research objects.According to the treatment scheme,the patients were divided into control group and observation group,with 45 cases in each group.Both groups were given routine treatment after admission,the control group added ezetimibe/simvoastatin,and the observation group added trimetazidine on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,LVDd and LVDs in the observation group were lower than those in the control group,while LVEF was higher than that in the control group(P<0.05).After treatment,the vWF and AngⅡlevel in the observation group were lower than those in the control group,while VEGF level was higher than that in the control group(P<0.05).After treatment,the MMP-9 and SAA levels in the observation group were lower than those in the control group(P<0.05).Conclusion Trimetazidine combined with ezetimibe/simvoastatin can improve the cardiac function and vascular endothelial function of elderly patients with coronary heart disease,and regulate the MMP-9 and SAA levels.It is worthy of clinical promotion and application.