C-藻蓝蛋白对肝脏损伤的保护作用及机制研究进展

Research progress of the protective effect and mechanism of C-phycocyanin on liver injury

C-藻蓝蛋白(C-PC)是一种来自海洋藻类的含色素蛋白质,在多种炎性疾病和肿瘤治疗中表现出良好的效果。其对药物或毒性物质引起的肝损害、非酒精性脂肪性肝病、肝纤维化和肝脏缺血再灌注损伤等多种肝病具有保护作用。C-PC对肝损伤的保护作用主要是通过调节核因子(NF)-κB、磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)和AMP依赖的蛋白激酶(AMPK)等信号通路及抑制氧化应激等机制实现的,且对正常细胞没有毒性。因此,C-PC作为一种潜在的天然保肝海洋活性物质具有广阔的应用前景。就近年来C-PC对肝脏损伤的保护作用及机制的研究进展进行综述。

C-phycocyanin(C-PC)is a pigmented protein from marine algae,which demonstrates fair therapeutic effects on a variety of inflammatory diseases and tumors.It also shows protective effects on various kinds of liver diseases,such as liver damage caused by drugs or toxic substances,non-alcoholic fatty liver disease,liver fibrosis and liver ischemiareperfusion injury.These beneficial effects on liver injury are mainly achieved by regulating the signal pathways of nuclear factor-κB(NF-κB),phosphatidylinositol 3 kinase/protein kinase B(PI3K/Akt)and adenosine monophosphate(AMP)-activated protein kinase(AMPK)and inhibiting oxidative stress.C-PC exhibits no toxicity to normal cells.Therefore,as a potential marine active substance for liver protection,C-PC has a broad application prospect.In this paper,the research progresses of the protective effect and mechanism of C-PC on different kinds of liver injury in recent years.