长链非编码RNA H19在纤维化疾病中的研究进展

Research progress of long non-coding RNA H19 in fibrotic diseases

纤维化疾病损害多种组织和器官,严重影响人类健康,现代医学尚缺乏有效的治疗方法。目前发现长链非编码RNA(LncRNA)H19在皮肤、肝、肺、心脏、肾等多种器官纤维化中存在差异性表达,表明LncRNA H19可能参与了纤维化疾病的发生及发展过程。该文总结了LncRNA H19与纤维化疾病发生发展的关系以及在各个器官中的作用,为纤维化疾病的诊断和防治提供新的思路。

Fibrotic diseases often cause damage to multiple tissues and organs,which still lack an effective therapy.At present,it has been found that long non-coding RNA(LncRNA)H19 is differentially expressed in fibrosis of skin,liver,lung,heart,kidney,and other organs,indicating that LncRNA H19 may be involved in the occurrence and development of fibrotic diseases.This article summarizes the relationship between LncRNA H19 and the development of fibrotic diseases and its role in various organs,which provides a new idea for the diagnosis,prevention,and treatment of fibrotic diseases.