免疫炎性相关指标及血浆D二聚体水平变化在慢性荨麻疹患者的检测价值

Detection Value of Immuno-inflammatory Related Indexes and Plasma D-dimer Changes in Patients with Chronic Urticaria

目的探讨免疫性相关指标及血浆D二聚体水平变化在慢性荨麻疹患者的检测价值。方法选取2019年1月-2021年1月于我院收治的80例慢性荨麻疹患者作为研究对象作为观察组,同时选择80例健康体检者作为对照组,通过免疫比浊法和酶联免疫法检测两组患者肿瘤坏死因子(TNF-α)水平、血清白介素-6(IL-6)水平和血浆D二聚体,通过受试者工作特征曲线(ROC)分析三者对慢性荨麻疹的应用价值;采用Person相关性分析各个指标与慢性荨麻疹发病机制的相关性。结果观察组患者血浆D二聚体、TNF-α和IL-6水平高于对照组(P>0.05)。免疫炎症相关指标水平和血浆D二聚体在慢性荨麻疹患者中的应用价值ROC分析(见表2,图1。)经过ROC分析显示,血浆D二聚体在慢性荨麻疹患者中检测价值AUC=0.798(95%CL=0.719~0.877,P<0.001);TNF-α在慢性荨麻疹患者中检测价值AUC=0.781(95%CL=0.698~0.863,P<0.001);IL6在慢性荨麻疹患者中的检测价值AUC=0.681(95%CL=0.582~0.781,P<0.001);血浆D二聚体、TNF-α和IL-6三者联合检测价值AUC=0.919(95%CL=0.869~0.968,P<0.001);D二聚体、TNF-α与IL-6均与慢性荨麻疹之间均呈正相关(r=0.557、0.580、0.658,P<0.05)。结论炎症因子IL-6、TNF-α和血浆D二聚体在慢性荨麻疹患者体内呈升高趋势,IL-6、TNF-α和血浆D二聚体水平与慢性荨麻疹发病机制有相关性,为临床治疗和疗效评估提供参考价值。

Objective To explore the detection value of immune related indexes and plasma D-dimer level in patients with chronic urticaria.Methods 80 patients with chronic urticaria treated in our hospital from January 2019 to January 2021 were selected as the observation group,and 80 healthy persons were selected as the control group.Tumor necrosis factor(TNF)was detected by immunoturbidimetry and enzyme-linked immunosorbent assay-α)Level,serum interleukin-6(IL-6)level and plasma D-dimer,the application value of the three to chronic urticaria was analyzed by receiver operating characteristic curve(ROC),and the correlation between each index and the pathogenesis of chronic urticaria was analyzed by person correlation.Results Plasma D-dimer,TNF-αand IL-6 levels in observation group were higher than those in control group(P>0.05).ROC analysis of the levels of immunoinflammation-related indicators and the application value of plasma D-dimer in patients with chronic urticaria(Table 2,Figure 1).ROC analysis showed that the detection value of plasma D-dimer in chronic urticaria patients was AUC=0.798(95%Cl=0.719-0.877,P<0.001).The value of TNF-αin chronic urticaria patients AUC=0.781(95%CL=0.698~0.863,P<0.001).The detection value of IL6 in chronic urticaria patients AUC=0.681(95%Cl=0.582~0.781,P<0.001);AUC value of plasma D-dimer,TNF-αand IL-6 combined detection was 0.919(95%Cl=0.869~0.968,P<0.001).D-dimer,TNF-αand IL-6 were positively correlated with chronic urticaria(R=0.557,0.580,0.658,P<0.05).Conclusion The levels of IL-6,TNF-αand plasma D-dimer were correlated with the pathogenesis of chronic urticaria,providing reference value for clinical treatment and efficacy evaluation.