丹参多酚酸盐联合艾司洛尔在老年冠心病心绞痛患者中的应用效果

Application effect of Salvianolate combined with Esmolol in elderly patients with coronary heart disease and angina pectoris

目的探讨丹参多酚酸盐联合艾司洛尔在老年冠心病心绞痛患者中的应用效果。方法选取2019年9月至2021年9月聊城市中医医院急诊科收治的98例老年冠心病心绞痛患者作为研究对象,采用随机数字表法将其分为观察组与对照组,每组各49例。对照组患者给予艾司洛尔治疗,观察组患者在对照组的基础上联合丹参多酚酸盐治疗。比较两组患者治疗前后的疗效、心功能、血流动力学、氧化应激指标与用药安全性。结果观察组患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的左室射血分数(LVEF)、左室舒张末期内径(LVEDD)与左室收缩末期内径(LVESD)比较,差异无统计学意义(P>0.05);治疗后,两组患者的LVEF高于治疗前,LVEDD与LVESD低于治疗前,且观察组患者的LVEF高于对照组,LVEDD与LVESD低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的纤维蛋白原、全血黏度高切、全血黏度低切及血浆黏度均低于治疗前,且观察组患者的纤维蛋白原、全血黏度高切、全血黏度低切及血浆黏度均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者的丙二醛(MDA)均低于治疗前,超氧化物歧化酶(SOD)均高于治疗前,且观察组患者的MDA低于对照组,SOD高于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论丹参多酚酸盐联合艾司洛尔治疗老年冠心病心绞痛可提升患者的心功能,改善血流动力学,降低氧化应激水平,疗效显著且安全性较好,应用价值较高。

Objective To explore the application effect of Salvianolate combined with Esmolol in elderly patients with coronary heart disease and angina pectoris.Methods A total of 98 elderly patients with coronary heart disease and angina pectoris admitted to the Department of Emergency,Liaocheng Hospital of Traditional Chinese Medicine from September 2019 to September 2021 were selected as the study subjects.They were divided into observation group and control group by random number table method,with 49 cases in each group.Control group was treated with Esmolol,and observation group was treated with Salvianolate on the basis of control group.The efficacy,cardiac function,hemodynamics,oxidative stress index and medication safety of the two groups were compared before and after treatment.Results The total effective rate of observation group was higher than that of control group,the difference was statistically significant(P<0.05).Before treatment,there were no statistically significant differences in left ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD)and left ventricular end systolic diameter(LVESD)between the two groups(P>0.05).After treatment,the LVEF of the two groups were higher than those before treatment,LVEDD and LVESD were lower than those before treatment,LVEF of observation group was higher than that of the control group,LVEDD and LVESD were lower than those of the control group,the differences were statistically significant(P<0.05).After treatment,fibrinogen,high whole blood viscosity,low whole blood viscosity and plasma viscosity in the two groups were lower than those before treatment,and fibrinogen,high whole blood viscosity,low whole blood viscosity and plasma viscosity in observation group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,malondialdehyde(MDA)in both groups were lower than those before treatment,superoxide dismutase(SOD)were higher than those before treatment,and the MDA level in observation group was lower than that in control group,SOD level was higher than that in control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Salvianolate combined with Esmolol in the treatment of angina pectoris in elderly patients with coronary heart disease can improve cardiac function,improve hemodynamics,reduce oxidative stress level,with significant efficacy and good safety,high application value.