骨髓脂肪细胞对机体造血调控作用的研究进展

The Regulatory Role of Bone Marrow Adipocytes in Hematopoiesis

骨髓腔是造血发生的场所,骨髓脂肪细胞(bone marrow adipocytes,BMAds)驻留在骨髓中,构成了骨髓腔中最大的细胞群体并与造血细胞密切接触。BMAds与成骨细胞共同起源于骨髓间充质干细胞(mesenchymal stem cells,MSCs)。骨髓脂肪对骨骼健康的重要性早已被认识,但其在造血调节中的复杂作用直到最近才受到关注。不同的研究团队报道的骨髓脂肪对造血的作用常常相互矛盾。阐明骨髓脂肪在不同条件下和造血系统之间的相互作用以及其调节机制有利于进一步了解骨髓微环境与造血干细胞(hematopoietic stem cells,HSCs)之间的关系,并可能为未来治疗造血相关疾病揭示新的靶点。该文将对BMAds在造血调控作用中的最新进展作一综述。

The bone marrow cavity is the place where hematopoiesis occurs.BMAds(bone marrow adipocytes)reside in the bone marrow and constitute the largest cell population in the bone marrow cavity closely contacting with hematopoietic cells.BMAds and osteoblasts originate from bone MSCs(marrow mesenchymal stem cells).The importance of bone marrow fat in bone health has long been recognized,but its complex role in regulating hematopoiesis has not attracted attention until recently.The effects of bone marrow fat on hematopoiesis reported by different research teams are often contradictory.Deciphering the regulatory mechanisms of bone marrow fat under different conditions in the hematopoietic system may be helpful to fully understand the complex bidirectional interactions between the bone marrow microenvironment and HSCs(hematopoietic stem cells).It may provide novel targets for hematological diseases in the future.This article will review the latest advances in the role of BMAds in hematopoiesis regulation.