血小板生成研究进展

Current Progress in Thrombopoiesis

血小板生成,即血小板颗粒由巨核细胞释放,进而在外周血逐步成熟的过程。随着解析血小板功能多样性以及高效再生策略的需求,对于血小板生成过程的全面认知显得尤为重要。然而,以往研究大多聚焦在造血干祖细胞和巨核细胞分化阶段,对于后期血小板生成过程的了解相对较少。该文对血小板生成过程中血小板形态、分子特征、功能的动态变化以及调控机制等进行了系统梳理,以期为理解血小板功能多样性、转录组异质性以及体外再生策略等方面提供新的思路。

Thrombopoiesis,the maturation process of platelets released by mature megakaryocytes,is the last part of platelet generation in the peripheral blood.Currently,with the deepening understanding of platelet functional diversity and the need of efficient generation strategy,it is important to have a comprehensive cognition of thrombopoiesis.While past researches tend to focus on the differentiation of hematopoietic stem/progenitor cells and megakaryocytes,very little attention has been paid to the process of thrombopoiesis.In this paper,the changes of platelet morphology,RNA content and variety,as well as the molecular features and functions during thrombopoiesis were systematically reviewed.It will provide new insights into the platelet functional diversity,transcriptome heterogeneity and in vitro generation strategies.