免疫性血小板减少症与机体免疫失衡

Immune Imbalance in Immune Thrombocytopenia

免疫性血小板减少症(ITP)是一种自身免疫性出血性疾病,多种免疫相关机制参与其中。B细胞产生抗血小板抗体介导巨噬细胞吞噬血小板被认为是ITP经典的发病机制。T细胞亚群以及相关细胞因子介导的细胞免疫失衡在ITP中也逐渐被证实。此外,抗原提呈细胞、间充质干细胞等免疫细胞失衡、基因表达异常、感染、代谢等因素造成的免疫微环境失调在ITP发病中的作用也逐渐受到重视。该文拟就ITP免疫机制以及相关研究进行综述。

ITP(immune thrombocytopenia)is an autoimmune bleeding disease in which multiple immune-related mechanisms are involved.Anti-platelet antibody produced by B cells to mediate platelet phagocytosis by macrophages is considered to be the classic pathogenesis of ITP.The imbalance of cellular immunity mediated by T cell subsets and related cytokines is gradually confirmed in ITP.In addition,the role of immune microenvironment disorders caused by the imbalance of immune cells such as antigen-presenting cells and mesenchymal stem cells,abnormal gene expression,infection,metabolism in the pathogenesis of ITP has gradually received attention.This study intends to review the immune mechanism of ITP and related research.