基于质谱的血液蛋白质组学:血液学研究的新焦点

MS-Based Blood Proteomics:Emerging Research Focus in Hematology

随着包括单细胞蛋白质组学在内的前沿蛋白质组学技术日趋成熟,其在血液学领域的应用也迅速扩展。该文简要介绍了基于质谱的蛋白质组学技术及其研究方法,讨论了血液蛋白质组学领域的最新研究进展,并对血浆/血清及外泌体蛋白质组学进行了分析与评述。最后对血液蛋白质组学的未来发展趋势进行了展望,预计临床血液蛋白质组学必将成为血液学下个十年的研究焦点之一。

With cutting-edge MS(mass spectrometry)-based proteomic technologies(e.g.single-cell proteomics)getting mature nowadays,their application in hematology is quickly expanding.This article briefly introduces MS-based proteomics,then reviews recent progress in blood proteomics,and further comments on the technological improvements of plasma/serum proteomics and the potential of extracellular vesicle proteomics.Finally,the future development of clinical blood proteome is prospected.Clinical blood proteomics will certainly become a research focus in near future.