基于“冲为血海”的分期针灸治疗多囊卵巢综合征冷冻胚胎移植的疗效观察

Efficacy observation of staged acupuncture and moxibustion therapy based on the theory of‘thorough fare vessel being sea of blood’on frozen-thawed embryo transfer in patients with polycystic ovary syndrome

目的:观察基于“冲为血海”的分期针灸疗法对冷冻胚胎移植(FET)多囊卵巢综合征(PCOS)患者的疗效。方法:将72例患者随机分为分期针灸组和对照组各36例,对照组采用FET方案,分期针灸组在对照组基础上配合基于“冲为血海”的分期针灸疗法。针灸治疗1周3次,连续治疗3个月经周期。观察两组治疗前后子宫内膜厚度及类型、血清激素水平[黄体生成素(LH)、促卵泡生成素(FSH)、LH/FSH、雌二醇(E2)、睾酮(T)]及临床妊娠率、活产率。结果:两组治疗前子宫内膜厚度及类型、血清激素LH、FSH、LH/FSH、E2、T差异无统计学意义。治疗后两组子宫内膜厚度增加,血清性激素LH、LH/FSH、T、E2下降,血清性激素FSH升高,差异有统计学意义(P<0.05);分期针灸组治疗后临床妊娠率、活产率显著高于对照组,子宫内膜厚度及A、B型内膜比例、血清性激素FSH显著高于对照组,血清性激素LH、LH/FSH、T、E2显著低于对照组(P<0.05)。结论:基于“冲为血海”的分期针灸疗法能有效改善行FET的PCOS患者子宫内膜厚度及类型、血清性激素水平,最终提高其临床妊娠率及活产率。

Objective:To observe the effect of staged acupuncture and moxibustion therapy based on the theory of‘thorough fare vessel being the sea of blood’on frozen-thawed embryo transfer(FET)in patients with polycystic ovary syndrome(PCOS).Methods:Seventy-two patients were randomly divided into two groups:the acupuncture group(36 cases)and the control group(36 cases)according to the principle of randomization.Control group used FET program,acupuncture group used staged acupuncture and moxibustion therapy based on the theory of thorough fare vessel being the sea of blood.Acupuncture and moxibustion treatment was performed 3 times a week,lasted for 3 menstrual cycles.Endometrial thickness and morphology,serum hormone levels(LH,FSH,LH/FSH,E_(2),T),clinical pregnancy rate and live birth rate were observed before and after treatment in two groups.Results:There were no statistically significant differences in endometrial thickness and morphology,serum hormone LH,FSH,LH/FSH,E_(2) and T between the two groups before treatment.After treatment,endometrial thickness increased,serum sex hormone LH,LH/FSH,T and E_(2) decreased,and serum sex hormone FSH increased,the differences were statistically significant(P<0.05).After treatment,the clinical pregnancy rate and live birth rate in stage acupuncture group were significantly higher than those in control group,the endometrial thickness,the proportion of type A and type B endometrial and the serum sex hormone FSH were significantly higher than those in control group,and the serum sex hormones LH,LH/FSH,T and E_(2) were significantly lower than those in control group(P<0.05).Conclusion:Staged acupuncture and moxibustion therapy based on the theory of‘thorough fare vessel being the sea of blood’can effectively improve the endometrial thickness and type,serum sex hormone level of patients receiving FET PCOS,and ultimately improve the clinical pregnancy rate and live birth rate.